Analyte detector

• US 7,368,085 B2
• Filed: 12/04/2003
• Issued: 05/06/2008
• Est. Priority Date: 12/04/2003
• Status: Active Grant

• Current Assignee: Honeywell International Inc.
• Original Assignee: Honeywell International Inc.
• Inventors: Gu, Yuandong, Lu, Son Thai
• Primary Examiner(s): SINES, BRIAN J
• Application Number:
  US10/727,891
• Publication Number:
  US 20050123442A1
• Time in Patent Office: 1,615 Days
• Field of Search: 422/50, 422/68.1, 422/82.01, 422/82.02, 436/43, 436/149, 436/91, 436/95, 257/1, 257/20, 257/192, 257/213, 600/300, 600/319, 600/316, 600/317, 600/345, 600/347, 600/365
• US Class Current: 422/82.01
• CPC Class Codes: G01N 33/66 involving blood sugars, e.g. galactose
• CPC Class Codes: Y10T 436/11 Automated chemical analysis
• CPC Class Codes: Y10T 436/14 Heterocyclic carbon compound [i.e. , O, S, N, Se, Te, as only ring hetero atom]
• CPC Class Codes: Y10T 436/144444 Glucose

Abstract

An analyte detector including a device having a surface, wherein the device is capable of detecting a charge adjacent to the surface. The surface includes a plurality of molecules bonded thereto, wherein the molecules have a structure (I):

where R is a ligand bonded to the surface of the device and R₁ is a spacer having 5 to 50 carbon atoms. The charge adjacent to the surface is created by the anionic complex of structure (I), and the number of anionic complex of structure (I) is dependent on the concentration of the analyte of interest. Methods for detecting an analyte are also disclosed, as well as systems using such analyte detectors.

Claims

1. An analyte detector comprising:

a field effect transistor having a gate surface; and

a monolayer of molecules, each molecule bonded to the gate surface, the molecules having a structure (II);

2. The analyte detector according to claim 1, wherein R₂ is a (C₁₀-C₂₀) alkylene.

3. The analyte detector according to claim 1, wherein R₃ is a phenylene or naphthalene.

4. The analyte detector according to claim 1, wherein the ligand is thiol, phosphate, or siloxane.

5. The analyte detector according to claim 1, wherein the gate surface is a conducting surface.

6. The analyte detector according to claim 1, wherein the gate surface is a non-continuous conducting surface of the field effect transistor, and the monolayer of molecules form a non-conducting layer on the non-continuous conducting surface.

7. The analyte detector according to claim 1, wherein the gate surface is an insulating surface.