PRRS vaccines

• US 7,368,117 B2
• Filed: 01/13/2006
• Issued: 05/06/2008
• Est. Priority Date: 01/13/2005
• Status: Active Grant

• Current Assignee: Boehringer Ingelheim Vetmedica GmbH (C.H. Boehringer Sohn AG & Co. KG)
• Original Assignee: Boehringer Ingelheim Vetmedica GmbH (C.H. Boehringer Sohn AG & Co. KG)
• Inventors: Pesch, Stefan, Fetzer, Christiane
• Primary Examiner(s): SALIMI, ALI REZA
• Application Number:
  US11/275,552
• Publication Number:
  US 20060286123A1
• Time in Patent Office: 844 Days
• Field of Search: 424/204.1, 435/6, 435/69.1
• US Class Current: 424/204.1
• CPC Class Codes: A61K 2039/5254 avirulent or attenuated
• CPC Class Codes: A61K 2039/552 Veterinary vaccine
• CPC Class Codes: A61K 39/12 Viral antigens
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 15/00 Drugs for genital or sexual disorders for disorders of sex hormones A61P5/24; Contraceptives
• CPC Class Codes: A61P 31/14 for RNA viruses
• CPC Class Codes: C12N 2770/10034 Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Abstract

The present invention is related to improved modified live PRRS vaccines of European genotype and new PRRSV strains which can be used for the manufacture of such vaccines.

Claims

1. A vaccine against Porcine Respiratory Reproductive Syndrome (PRRS) which comprises live PRRS virus, characterized in that it contains one or more of the PRRS virus strains that have been deposited on 27 Oct. 2004 with the European Collection of Cell Cultures (ECACC), Porton Down, Salisbury, Wiltshire, SP4 0JG, Great Britain, under the Accession Numbers ECACC 04102703, ECACC 04102702, and ECACC 04102704, or a descendant of one or more of the aforementioned strains, with a pharmaceutically acceptable carrier, but not the strain deposited under the Accession Number ECACC 04102701.

2. The vaccine of claim 1, comprising the PRRS virus strains that have been deposited under the Accession Numbers ECACC 04102703, ECACC 04102702, and ECACC 04102704.

3. The vaccine of claim 1 or claim 2, further comprising an adjuvant.

4. The vaccine of claim 3, wherein the adjuvant is (α

-tocopherol acetate.

5. The vaccine of claim 1, wherein the PRRS virus is present as a freeze-dried composition of such virus.

7. A vaccine product, comprising in separate containers a freeze-dried composition according to claim 5, and a solvent for reconstitution.

8. The vaccine product as recited in claim 7 further comprising a leaflet or label with instructions for use.

9. The vaccine product of claim 7, wherein the solvent contains an adjuvant.

10. A method of vaccinating a pig against PRRS, comprising administering a vaccine or vaccine product according to claim 1 to such pig.

11. The vaccine according to claim 1, further characterised in that it comprises at least one further antigen active against a porcine disease which is not PRRS.

6. A PPRS virus strain which is any one of the PRRS virus strains that have been deposited on 27 Oct. 2004 with the European Collection of Cell Cultures (ECACC), Porton Down, Salisbury, Wiltshire, SP4 0JG, Great Britain, under the Accession Numbers ECACC 04102703, ECACC 04102702, and ECACC 04102704, or a descendant of any one of the aforementioned strains.