Amphiphilic materials and liposome formulations thereof
First Claim
1. A liquid-crystalline multimolecular aggregate comprising a plurality of amphiphilic molecules dispersed in an aqueous solution, said amphiphilic molecules comprising a hydrophilic component having at least a first and second terminus and at least a first and second hydrophobic moiety separately attached to, or proximal to, said first and second terminus of said hydrophilic component.
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Accused Products
Abstract
Disclosed is a new structural class of amphiphilic molecules which incorporate a hydrophilic material or polymer attached, at spatially distinct sites, to at least two hydrophobic residues. Certain of the amphiphilic molecules comprise a plurality of hydrophobic moieties. All such amphiphilic molecules have a common structural motif and, in contact with water, display surface activity and self-assemble into multimolecular aggregates and liquid crystalline phases. Also disclosed are enhanced stability liposomes that incorporate such amphiphilic molecules via unique interactions, and methods of using such formulations in a variety of applications including drug delivery, nutrition, bio-diagnostics, cosmetics, blood products and related applications.
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Citations
46 Claims
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1. A liquid-crystalline multimolecular aggregate comprising a plurality of amphiphilic molecules dispersed in an aqueous solution, said amphiphilic molecules comprising a hydrophilic component having at least a first and second terminus and at least a first and second hydrophobic moiety separately attached to, or proximal to, said first and second terminus of said hydrophilic component.
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2. A liposome or lipid complex comprising amphiphilic molecules that comprise a hydrophilic component positioned over at least a portion of the outer surface of said liposome or lipid complex;
- wherein said hydrophilic component has at least a first and second terminus and at least a first and second hydrophobic moiety separately attached to, or proximal to, said first and second terminus, wherein said first and second hydrophobic moieties extend into the hydrophobic bilayer of said liposome or lipid complex.
- View Dependent Claims (3)
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4. A method of making a liposome or lipid complex comprising admixing, an aqueous solution or phase, a population of lipid components with a population of amphiphilic molecules, the said amphiphilic molecules being taken as such or in a prehydrated state;
- wherein said amphiphilic molecules comprise a hydrophilic component having at least a first and second terminus and at least a first and second hydrophobic moiety separately attached to, or proximal to, said first and second terminus; and
optionally a selected agent comprising a chemical or a biological agent or a biological cell; and
wherein said admixing is effective to form said liposome or lipid complex, to encapsulate or trap the said selected agent if provided. - View Dependent Claims (5, 6, 7, 8, 9, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46)
- wherein said amphiphilic molecules comprise a hydrophilic component having at least a first and second terminus and at least a first and second hydrophobic moiety separately attached to, or proximal to, said first and second terminus; and
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10. A kit comprising, in a suitable container, amphiphilic molecules comprising a hydrophilic component having at least a first and second terminus and at least a first and second hydrophobic moiety separately attached to, or proximal to, said first and second terminus;
- or a liposomal formulation comprising said amphiphilic molecule.
Specification