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Polymerase chain reaction using metallic glass-coated microwire

  • US 7,368,166 B2
  • Filed: 04/04/2005
  • Issued: 05/06/2008
  • Est. Priority Date: 04/06/2004
  • Status: Expired due to Fees
First Claim
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1. A metallic glass-coated microwire having a metallic core, wherein said glass has a thermal contraction coefficient less than that of said metallic core by a preselected value, said preselected value being such that said glass is under residual compression, interfacial bonding between said glass and said metallic core is substantially uniform, and surface cracking and bond breaks between metal and glass are substantially prevented, said glass coating having a controllable amount and configuration of surface porosity defined by a plurality of pores in a surface of said glass coating and at least some of said pores being filled with reagents for PCR in order to detect specific biological species.

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