Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof
First Claim
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1. An isolated polypeptide comprising the amino acid sequence encoded by SEQ ID NO:
- 24.
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Abstract
Disclosed herein are non-endogenous, constitutively activated forms of the human 5-HT2A and human 5-HT2C receptors and uses of such receptors to screen candidate compounds. Further disclosed herein are candidate compounds identified by the screening method which act at the 5HT2A receptors. Yet further disclosed is a new class of compounds which act at the 5HT2A receptors.
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1 Claim
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1. An isolated polypeptide comprising the amino acid sequence encoded by SEQ ID NO:
- 24.
Specification
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Current AssigneeArena Pharmaceuticals Incorporated
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Original AssigneeArena Pharmaceuticals Incorporated
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InventorsChalmers, Derek T., Liaw, Chen W., Thomsen, William J., Behan, Dominic P., Russo, Joseph F.
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Primary Examiner(s)Saoud; Christine J.
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Assistant Examiner(s)BASI, NIRMAL SINGH
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Application NumberUS10/980,560Publication NumberTime in Patent Office1,281 DaysField of SearchNoneUS Class Current530/350CPC Class CodesC07D 231/12 with only hydrogen atoms, h...C07D 231/16 Halogen atoms or nitro radi...C07D 409/12 linked by a chain containin...C07K 14/70571 for neuromediators, e.g. se...C07K 14/723 G protein coupled receptor,...G01N 2333/70571 for neuromediators, e.g. se...G01N 2333/726 G protein coupled receptor,...G01N 33/566 using specific carrier or r...
