Method and arrangement for influencing magnetic particles and detecting interfering material

• US 7,370,656 B2
• Filed: 04/05/2004
• Issued: 05/13/2008
• Est. Priority Date: 04/15/2003
• Status: Active Grant

• Current Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Original Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Inventors: Gleich, Bernhard, Weizenecker, Jurgen
• Primary Examiner(s): Lacyk; John P
• Application Number:
  US10/552,801
• Publication Number:
  US 20070007486A1
• Time in Patent Office: 1,499 Days
• Field of Search: 128/899, 606 27- 31, 607/103, 600 9- 15, 219/634
• US Class Current: 128/899
• CPC Class Codes: A61B 5/0515 Magnetic particle imaging
• CPC Class Codes: A61N 1/406 using implantable thermoseeds or injected particles for localized hyperthermia preparations of seeds and particles A61K41/0052
• CPC Class Codes: A61N 2/02 using magnetic fields produced by coils, including single turn loops or electromagnets A61N2/12 takes precedence

Abstract

The invention relates to a method and an arrangement for influencing magnetic particles in a region of action. Methods and arrangements of this kind can be used to determine the spatial distribution of magnetic particles in the region of action or to heat up the magnetic particles locally. If, in addition to the magnetic particles, there is also interfering material in the region of action then this material may heat up in an unwanted way. To avoid unwanted heating-up of this kind, any interfering material that may be present is detected beforehand. If there is interfering material present, then an examination or investigation, or treatment, can be carried out with changed system parameters.

Claims

1. A method for influencing, in a region of action, magnetic particles that have been introduced into an object, the method comprising:

a) detecting an interfering material in or on the object,

b) generating a magnetic field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the region of action,

c) changing the position in space of the two sub-zones in the region of action so that the magnetization of the particles changes locally, and

d) acquiring signals that depend on the magnetization in the region of action, which magnetization is influenced by the above change in position.

2. A method as claimed in claim 1, wherein detecting of the interfering material is performed before the magnetic particles are introduced, by measuring the change in the inductance of an inductive means that is the result of a change in the distance between the object and the inductive means.

3. A method as claimed in claim 2, wherein the inductive means comprises a coil used in the generation of the magnetic field, in the change in the position in space of the sub-zones and, where applicable, in the acquisition of the signals.

4. A method as claimed in claim 1, wherein, for the detecting, steps b) to d) are performed for a first time with a lower spatial resolution, or at a lower speed, or both, and the signals acquired are analyzed to obtain information at least on the presence of interfering material.

5. A method as claimed in claim 4, wherein the magnetic particles are not introduced into the object until after the detection.

6. A method as claimed in claim 4, wherein the magnetic particles are introduced into the object before the detection and wherein, in the analysis, the signals acquired are examined for signal components that derive from interfering material.

7. a method as claimed in claim 6, wherein interfering material is detected from the spectral composition of the signals acquired.

8. A method as claimed in claim 1, wherein, if interfering material is present, magnetic fields having a reduced temporal variation are used during the influencing of the magnetic particles to change the position in space of the two sub-zones.

9. A method as claimed in claim 1, wherein, if interfering material is present, steps b) and c) are performed with a reduced spatial resolution during the influencing of the magnetic particles.

10. An arrangement for influencing magnetic particles in a region of action, comprising:

a) means for detecting interfering material,

b) means for generating a magnetic field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the region of action,

c) means for changing the position in space of the two sub-zones in the region of action, and

d) means for acquiring signals, which signals depend on the magnetization in the region of action that is influenced by the change in the position in space of the sub-zones.

11. An arrangement as claimed in claim 10, further comprising means for measuring the inductance of at least one of an inductive means that are used for the generation of the magnetic field, for the change in the position in space of the sub-zones and/or for the acquisition of the signals.

12. An arrangement as claimed in claim 10 further comprising an analyzing unit to obtain information on at least the presence of interfering material.

13. An arrangement as claimed in claim 12, wherein the analyzing unit is adapted to examine the signals acquired for signal components deriving from magnetic particles and also from interfering material.