System and method for real-time apnea/hypopnea detection using an implantable medical system

• US 7,371,220 B1
• Filed: 06/30/2004
• Issued: 05/13/2008
• Est. Priority Date: 06/30/2004
• Status: Active Grant

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Koh, Steve, Benser, Michael, Park, Euljoon
• Primary Examiner(s): Nasser, Jr.; Robert L.
• Assistant Examiner(s): Toth; Karen E
• Application Number:
  US10/883,857
• Time in Patent Office: 1,413 Days
• Field of Search: 600/529, 600/533
• US Class Current: 600/529
• CPC Class Codes: A61B 5/0809 by impedance pneumography
• CPC Class Codes: A61B 5/4519 Muscles A61B5/389, A61B5/224 take precedence
• CPC Class Codes: A61B 5/4818 Sleep apnoea
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives

Abstract

Techniques are provided for detecting the onset of an episode of apnea/hypopnea substantially in real-time. A moving threshold is generated based on recent respiration cycles and differences are accumulated between amplitudes of new respiration cycles and the moving threshold. Apnea/hypopnea is then detected based upon a comparison of the accumulated differences against a fixed threshold. The technique exploits the fact that many episodes of hypopnea begin with a sharp drop in respiration and many episodes of apnea are preceded by a sharp drop in respiration. By accumulating differences between new respiration amplitudes and a short term moving average, any sharp drop in respiration is thereby promptly detected. In many cases, by the time the amplitudes of individual respiration cycles drop to levels directly indicative of apnea/hypopnea, the episode of apnea/hypopnea will have already been detected based upon the sudden sharp drop in respiration amplitude and therapy will have already been initiated.

Claims

1. A method for detecting the onset of an episode of reduced respiration within a patient using an implantable medical device, the method comprising:

generating a moving threshold based on recent respiration cycles;

accumulating a sum of the differences between amplitudes of new respiration cycles and the moving threshold; and

detecting the onset of an episode of reduced breathing based upon the accumulated differences.

2. The method of claim 1 wherein detecting the onset of an episode of reduced breathing is performed to detect one or more of apnea and hypopnea.

3. The method of claim 1 wherein generating a moving threshold is performed based on a predetermined number of respiration cycles.

4. The method of claim 3 wherein the predetermined number of respiration cycles is three.

5. The method of claim 1 wherein generating a moving threshold is performed based on respiration cycles detected within a predetermined fixed interval of time.

6. The method of claim 1 wherein generating a moving threshold based on recent respiration cycles is performed using thoracic impedance values and wherein the method further comprises:

activating a timer after detection of each new respiration cycle; and

if the timer expires before a next respiration cycle is detected, updating the moving threshold based on recent thoracic impedance values regardless of whether the thoracic impedance values conform to an identifiable respiration cycle.

7. The method of claim 1 wherein the moving threshold is based on weighted combinations of mean and standard deviations in amplitudes of the recent respiration cycles.

8. The method of claim 1 wherein generating the moving threshold comprises:

calculating amplitude values associated with each of the recent respiration cycles;

calculating mean values associated with each of the recent respiration cycles;

calculating standard deviation values associated with each of the recent respiration cycles; and

calculating the moving threshold based on weighted sums of the mean values and the standard deviation values.

9. The method of claim 8 wherein calculating amplitude values comprises:

tracking thoracic impedance Z(t) using leads implanted within the chest;

calculating the derivative (dZ/dt) of thoracic impedance;

identifying respiration cycles by identifying consecutive zero crossing points in the derivative of thoracic impedance that are associated with inspiration; and

calculating the amplitude of a respiratory cycle by integrating the derivative of the thoracic impedance between consecutive zero crossing points associated with inspiration.

10. The method of claim 1 wherein accumulating differences between amplitudes of new respiration cycles and the moving threshold is performed only while the amplitudes of the new respiration cycles fall below the moving detection threshold.

11. The method of claim 1 wherein detecting the onset of an episode of reduced respiration based upon the accumulated differences is performed by comparing the accumulated differences against a fixed detection threshold.

12. The method of claim 1 wherein accumulating differences between amplitudes of respiration cycles and the moving threshold is performed substantially continuously.

13. The method of claim 1 wherein detecting the onset of an episode of reduced respiration based upon the accumulated differences is performed by comparing the accumulated differences against a fixed episode detection threshold.

14. The method of claim 13 further comprising detecting the end of an episode of reduced respiration based upon the accumulated differences by comparing the accumulated differences against a fixed episode end threshold.

15. The method of claim 1 further comprising delivering therapy upon detection of an episode of reduced respiration.

16. The method of claim 15 wherein the implantable device is equipped to deliver overdrive pacing therapy to the heart of the patient and wherein delivering therapy comprises delivering overdrive pacing therapy to the heart of the patient.

17. The method of claim 16 wherein the overdrive pacing therapy is dynamic atrial overdrive (DAO) pacing therapy.

18. The method of claim 15 wherein an implantable drug pump is provided and wherein delivering therapy comprises selectively delivering drug therapy to the patient using the drug pump.

19. The method of claim 15 further comprising determining whether a current episode of reduced respiration is associated with central sleep apnea (CSA).

20. The method of claim 19 for use with a system having an implantable phrenic nerve sensor and wherein determining whether the current episode of reduced respiration is associated with CSA is performed based on the signals received from the phrenic nerve sensor.

21. The method of claim 19 for use with a system having an implantable phrenic nerve stimulator and wherein, if the episode of reduced respiration is associated with CSA, therapy includes application of stimulation to the phrenic nerves using the phrenic nerve stimulator.

22. The method of claim 15 further comprising determining whether a current episode of reduced respiration is associated with obstructive sleep apnea (OSA).

23. The method of claim 22 for use with a system having an implantable phrenic nerve sensor and wherein determining whether the current episode of reduced respiration is due to OSA is performed based on the signals received from the phrenic nerve sensor.

24. The method of claim 22 for use with a system having an implantable upper airway sensor and wherein determining whether the current episode of reduced respiration is associated with OSA is performed based on signals received from the upper airway sensor.

25. The method of claim 22 for use with a system having an implantable upper airway stimulator mounted near the soft palate of the patient and wherein, if the episode of reduced respiration is associated with OSA, therapy includes application of stimulation to the muscles near the soft palate using the upper airway stimulator.

26. The method of claim 15 further comprising determining whether a current episode of reduced respiration is associated with Cheyne-Stokes Respiration (CSR).

27. The method of claim 26 wherein determining whether the current episode of reduced respiration is associated CSR is performed based on detection of alternating cycles of relatively reduced and increased breathing.

28. The method of claim 26 for use with a system having an implantable phrenic nerve stimulator and wherein, if the episode of reduced respiration is associated with CSR, therapy includes application of stimulation to the phrenic nerves using the phrenic nerve stimulator.

29. The method of claim 1 further comprising generating a warning signal in response to an episode of reduced respiration sufficient to alert the patient.

30. The method of claim 29 wherein generating a warning signal comprises one or more of:

transmitting a signal to an external alarm device;

electrically stimulating selected muscles of the patient to cause the muscles to twitch using an implantable electrical stimulator; and

controlling an implantable device to vibrate.

31. The method of claim 1 for use with a system having an implantable blood oxygen sensor and further comprising confirming detection of the episode of reduced respiration based on signals received from the blood oxygen sensor.

32. The method of claim 1 further comprising recording diagnostic information representative of episodes of reduced respiration.

33. A system for detecting an episode of substantially reduced respiration within a patient using an implantable medical device, the system comprising:

circuitry operative to receive signals representative of amplitudes of respiration cycles; and

a detection unit operative to detect an episode of reduced respiration based upon an accumulating a sum of the differences between amplitudes of new respiration cycles and a moving threshold generated based on the amplitudes of previous respiration cycles.

34. A system for detecting an episode of substantially reduced respiration within a patient using an implantable medical device, the system comprising:

means for detecting amplitudes of respiration cycles;

means for generating a moving threshold based on amplitudes of recent respiration cycles;

means for accumulating a sum of the differences between amplitudes of new respiration cycles and the moving threshold; and

means for detecting the onset of an episode of substantially reduced breathing based upon the accumulated differences.