Valved prosthesis with porous substrate
First Claim
1. An implantable prosthesis comprising:
- at least one occluder, wherein the at least one occluder comprises a rigid material with pores formed in the rigid material, wherein the rigid material is selected from the group consisting of metals, carbonaceous solids, polymers, and ceramics; and
a filler comprising a hydrogel or a structural protein or a bioactive agent or mixtures thereof, the filler being located within the pores, wherein said rigid porous material with the filler presents a smoother surface for fluid flow than pores without filler and wherein the filler prevents back flow of fluid through the pores of the occluder.
1 Assignment
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Accused Products
Abstract
An implantable prosthesis can be formed from an improved biocompatible material that provides for cellular colonization of the biocompatible material. Specifically, the biocompatible material is a rigid porous material. In embodiments of particular interest, the implantable prosthesis is a mechanical heart valve prosthesis with a rigid occluder. In some embodiments, the rigid occluder is formed from the biocompatible material. A filler comprising a hydrogel or a structural protein can be located within the pores. In some embodiments, a bioactive agent is within the pores. In some embodiments, the rigid occluder is formed from a polymer material, a carbonaceous solid or a ceramic material. The pores can extend through the rigid material.
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Citations
37 Claims
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1. An implantable prosthesis comprising:
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at least one occluder, wherein the at least one occluder comprises a rigid material with pores formed in the rigid material, wherein the rigid material is selected from the group consisting of metals, carbonaceous solids, polymers, and ceramics; and a filler comprising a hydrogel or a structural protein or a bioactive agent or mixtures thereof, the filler being located within the pores, wherein said rigid porous material with the filler presents a smoother surface for fluid flow than pores without filler and wherein the filler prevents back flow of fluid through the pores of the occluder. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. An implantable medical device comprising;
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at least one occluder, wherein the at least one occluder comprises a rigid material having pores formed in the rigid material and present substantially close to a surface of the rigid material, wherein the rigid material is selected from the group consisting of metals, carbonaceous solids, polymers, and ceramics; and a filler, said filler comprising a hydrogel or a structural protein or a bioactive agent or mixtures thereof, the filler being located within the pores to promote cellular attachment and proliferation and wherein the filler prevents back flow of fluid through the pores of the occluder. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30)
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31. An implantable medical device comprising;
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at least one occluder, wherein the at least one occluder comprises a rigid material having pores substantially extending through the rigid material to form a porous network, wherein the rigid material is selected from the group consisting of metals, carbonaceous solids, polymers, and ceramics; and a filler, said filler comprising a hydrogel or a structural protein or a bioactive agent or mixtures thereof, the filler being located within the pores, and said porous network does not provide significant blood flow through the porous material and wherein the filler prevents back flow of fluid through the pores of the occluder. - View Dependent Claims (32, 33, 34, 35, 36, 37)
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Specification