Apparatus and method for mixing a film of fluid
First Claim
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1. A method for forming an apparatus, said method comprising:
- providing first and second substrates and a seal;
placing the second substrate on top of the seal placed on the first substrate so as to define a closed chamber therebetween, said chamber adapted to retain a quantity of fluid so that the fluid is in contact with both inner surfaces, wherein;
at least one of said inner surfaces is functionalized with polynucleotides, polypeptides, or polysaccharides;
at least one of said first and second substrates comprises a means for nucleating a bubble; and
at least one of said first and second substrates and said seal comprises an opening for introducing fluid into the closed chamber; and
introducing a fluid into the closed chamber so as to provide a quantity of fluid therein in contact with both inner surfaces.
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Abstract
A method and apparatus is provided for mixing a film of fluid, particularly a film of chemical, biochemical, or biological fluids undergoing a reaction. The apparatus comprises a means for nucleating a bubble using a discrete heat source, such as a resistor, and moving the bubble in the fluid by creating a temperature gradient, thereby mixing the fluid.
40 Citations
23 Claims
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1. A method for forming an apparatus, said method comprising:
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providing first and second substrates and a seal; placing the second substrate on top of the seal placed on the first substrate so as to define a closed chamber therebetween, said chamber adapted to retain a quantity of fluid so that the fluid is in contact with both inner surfaces, wherein; at least one of said inner surfaces is functionalized with polynucleotides, polypeptides, or polysaccharides; at least one of said first and second substrates comprises a means for nucleating a bubble; and at least one of said first and second substrates and said seal comprises an opening for introducing fluid into the closed chamber; and introducing a fluid into the closed chamber so as to provide a quantity of fluid therein in contact with both inner surfaces. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. An apparatus comprising:
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first and second substrates and a seal, wherein the second substrate is positioned on top of the seal placed on the first substrate so as to define a closed chamber therebetween, said chamber retaining a quantity of fluid therein so that the fluid is in contact with both inner surfaces, and wherein; at least one of said inner surfaces is functionalized with polynucleotides, polypeptides, or polysaccharides; at least one of said first and second substrates comprises a means for nucleating a bubble; and at least one of said first and second substrates and said seal comprises an opening for introducing/fluid into the closed chamber. - View Dependent Claims (19, 20, 21, 22, 23)
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Specification