Wound dressing and method for controlling severe, life-threatening bleeding

• US 7,371,403 B2
• Filed: 12/23/2003
• Issued: 05/13/2008
• Est. Priority Date: 06/14/2002
• Status: Expired due to Term

• Current Assignee: Providence Health System - Oregon
• Original Assignee: Kenton W. Gregory, Providence Health System - Oregon
• Inventors: Campbell, Todd D., Wiesmann, William P., Gregory, Kenton W., McCarthy, Simon J.
• Primary Examiner(s): Kennedy; Sharon E.
• Application Number:
  US10/743,052
• Publication Number:
  US 20040243043A1
• Time in Patent Office: 1,603 Days
• Field of Search: 424/445, 424/520, 424/538, 514/55, 536/20
• US Class Current: 424/445
• CPC Class Codes: A61F 13/00063 comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic drug delivery dressings A61K9/70; chemical aspect of the additives A61L15/00
• CPC Class Codes: A61F 13/0203 with fluid retention members
• CPC Class Codes: A61F 13/0253 characterized by the adhesive material
• CPC Class Codes: A61F 13/0256 characterized by the parametric properties of the adhesive
• CPC Class Codes: A61F 13/0276 Apparatus or processes for manufacturing adhesive dressings or bandages
• CPC Class Codes: A61F 13/0289 manufacturing of adhesive dressings
• CPC Class Codes: A61F 13/36 Surgical swabs, e.g. for absorbency or packing body cavities during surgery A61F13/38 takes precedence
• CPC Class Codes: A61F 17/00 First-aid kits
• CPC Class Codes: A61F 2013/00106 emergency bandages, e.g. for first aid
• CPC Class Codes: A61F 2013/00221 biodegradable, non-irritating
• CPC Class Codes: A61F 2013/00463 haemostatic
• CPC Class Codes: A61F 2013/00468 applying local pressure
• CPC Class Codes: A61F 2013/00472 with chemical means
• CPC Class Codes: A61F 2013/0054 for deep wounds
• CPC Class Codes: A61F 2013/00659 polymeric base
• CPC Class Codes: A61F 2013/00676 hydrogel
• CPC Class Codes: A61F 2013/0071 containing active agent
• CPC Class Codes: A61F 2013/00719 adhesives for use on wounds
• CPC Class Codes: A61F 2013/00931 chitin
• CPC Class Codes: A61F 5/40 Suspensory bandages
• CPC Class Codes: A61L 15/28 : Polysaccharides or their derivatives A61L15/225 takes precedence
• CPC Class Codes: A61L 15/425 : Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 2400/04 : Materials for stopping bleeding
• CPC Class Codes: A61P 17/02 : for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: C08L 1/00 : Compositions of cellulose, modified cellulose or cellulose derivatives
• CPC Class Codes: C08L 5/08 : Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

Abstract

This invention is directed to advanced hemorrhage control wound dressings, and methods of using and producing same. The subject wound dressing is constructed from a non-mammalian material for control of severe bleeding. The wound dressing for controlling severe bleeding is formed of a biomaterial comprising chitosan, a hydrophilic polymer, a polyacrylic polymer or a combination thereof. The kind of severe, life-threatening bleeding contemplated by this invention is typically of the type not capable of being stanched when a conventional gauze wound dressing is applied with conventional pressure to the subject wound. The wound dressing being capable of substantially stanching the flow of the severe life-threatening bleeding from the wound by adhering to the wound site, to seal the wound, to accelerate blood clot formation at the wound site, to reinforce clot formation at the wound site and prevent bleed out from the wound site, and to substantially prohibit the flow of blood out of the wound site.

Claims

1. A wound dressing comprising a compressed composite sponge comprising a freeze-dried and heat-compressed structure comprising a chitosan biomaterial having a density, after being heat-compressed, of between about 0.14 g/cm³ to about 0.6 g/cm³, the freeze-dried and heat-compressed structure being sized and configured for shaping by hand for insertion into a wound site into contact with tissue for hemorrhage control, the freeze-dried and heat-compressed structure having a degree of adhesion to the wound site of about 40 kPa to about 500 kPa to adhere to tissue in the presence of blood flow and stanch bleeding within the wound site.

2. A wound dressing according to claim 1, wherein the compressed composite sponge has a degree of adhesion to the wound site of about 60 kPa to about 250 kPa.

3. A wound dressing according to claim 1, wherein the compressed composite sponge has a degree of adhesion to the wound site of about 100 kPa to about 200 kPa.

4. A wound dressing according to claim 1, wherein the chitosan biomaterial has a pH of not more than about 5.5 when bleeding is stanched.

5. A wound dressing according to claim 1, wherein the chitosan biomaterial has a pH of not more than about 4.5 when bleeding is stanched.

6. A wound dressing according to claim 1, wherein the chitosan biomaterial has a pH of not more than about 4.0 when bleeding is stanched.

7. A wound dressing according to claim 1, wherein the chitosan biomaterial comprises an acid selected from the group consisting of acetic acid, formic acid, lactic acid, ascorbic acid, hydrochloric acid, and citric acid.