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Method and apparatus for determining base sequence of nucleic acid molecule

  • US 7,371,532 B2
  • Filed: 09/22/2005
  • Issued: 05/13/2008
  • Est. Priority Date: 09/28/2004
  • Status: Active Grant
First Claim
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1. A method for determining the base sequence of a nucleic acid molecule, wherein the nucleic acid molecule is immobilized on a cantilever comprising a piezoelectric element, said method comprisinga) measuring the frequency of vibration of the piezoelectric element;

  • b) cleaving the nucleic acid molecule;

    c) measuring the frequency of vibration of the piezoelectric element; and

    d) determining the sequence of the nucleic acid molecule by comparing the frequency measured in a) with the frequency measured in c).

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