Peelable and resealable devices for biochemical assays
First Claim
Patent Images
1. A kit for forming a device comprising:
- a base plate;
a first removable member adapted to repeatedly self-seal on the base plate,the first removable member defining at least one first orifice therein and having walls bounding the at least one first orifice on sides of the at least one first orifice,the first removable member being in self-sealing contact with the base plate for defining at least one first well corresponding to a respective one of the at least one first orifice;
a second removable member adapted to repeatedly self-seal on at least one of the first removable member and the base plate,the second removable member defining at least one second orifice therein and having walls bounding the at least one second orifice on sides of the at least one second orifice,the second removable member being in self-sealing contact with one of the first removable member and the base plate for defining at least one second well corresponding to a respective one of the at least one second orifice,wherein said at least one second orifice is smaller than said at least one first orifice; and
at least one registration element adapted to align the base plate, the first removable member, and the second removable member with one another.
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Accused Products
Abstract
Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the flat surface, then removed to yield a flat surface that facilitates the performance of processes on and/or detection of the immobilized material.
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Citations
37 Claims
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1. A kit for forming a device comprising:
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a base plate; a first removable member adapted to repeatedly self-seal on the base plate, the first removable member defining at least one first orifice therein and having walls bounding the at least one first orifice on sides of the at least one first orifice, the first removable member being in self-sealing contact with the base plate for defining at least one first well corresponding to a respective one of the at least one first orifice; a second removable member adapted to repeatedly self-seal on at least one of the first removable member and the base plate, the second removable member defining at least one second orifice therein and having walls bounding the at least one second orifice on sides of the at least one second orifice, the second removable member being in self-sealing contact with one of the first removable member and the base plate for defining at least one second well corresponding to a respective one of the at least one second orifice, wherein said at least one second orifice is smaller than said at least one first orifice; and at least one registration element adapted to align the base plate, the first removable member, and the second removable member with one another. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A kit for forming a device comprising:
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a base plate; a first removable member adapted to repeatedly self-seal on the base plate, the first removable member defining at least one first orifice therein and having walls bounding the at least one first orifice on sides of the at least one first orifice, the first removable member being in self-sealing contact with the base plate for defining at least one first well corresponding to a respective one of the at least one first orifice; a second removable member adapted to repeatedly self-seal on at least one of the first removable member and the base plate, the second removable member defining at least one second orifice therein and having walls bounding the at least one second orifice on sides of the at least one second orifice, the second removable member being in self-sealing contact with one of the first removable member and the base plate for defining at least one second well corresponding to a respective one of the at least one second orifice, wherein said at least one second orifice is smaller than said at least one first orifice; and at least one registration element adapted to align the base plate, the first removable member, and the second removable member with one another within 200 microns in all directions.
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25. A kit for forming a device comprising:
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a base plate; a first removable member adapted to repeatedly self-seal on the base plate, the first removable member defining at least one first orifice therein and having walls bounding the at least one first orifice on sides of the at least one first orifice, the first removable member being in self-sealing contact with the base plate for defining at least one first well corresponding to a respective one of the at least one first orifice; a second removable member adapted to repeatedly self-seal on at least one of the first removable member and the base plate, the second removable member defining at least one second orifice therein and having walls bounding the at least one second orifice on sides of the at least one second orifice, the second removable member being in self-sealing contact with one of the first removable member and the base plate for defining at least one second well corresponding to a respective one of the at least one second orifice, wherein said at least one second orifice is smaller than said at least one first orifice; and at least one registration element adapted to align the base plate, the first removable member, and the second removable member with one another in only one specific orientation. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
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Specification