Self-assembly of peptide-amphiphile nanofibers under physiological conditions
First Claim
Patent Images
1. A sol-gel composition comprising (i) a peptide amphiphile compound having a net charge at physiological pH which comprises a peptide component containing a peptidic epitope sequence, a hydrophobic component which is not peptide, and residues for intermolecular disulfide bond formation, wherein said epitope sequence is selected from RGD, IKVAV (SEQ ID NO:
- 45) and YIGSR (SEQ ID NO;
46), and (ii) a metal ion to induce gelation of said amphiphile compound whereby the composition forms a gel of supramolecular nanofibers of said amphiphile compound in the presence of said reagent, wherein said reagent comprises metal ion in stoichiometric excess of said amphiphile compound.
3 Assignments
0 Petitions
Accused Products
Abstract
Peptide amphiphile compounds, compositions and methods for self-assembly or nanofibrous network formation under neutral or physiological conditions.
-
Citations
5 Claims
-
1. A sol-gel composition comprising (i) a peptide amphiphile compound having a net charge at physiological pH which comprises a peptide component containing a peptidic epitope sequence, a hydrophobic component which is not peptide, and residues for intermolecular disulfide bond formation, wherein said epitope sequence is selected from RGD, IKVAV (SEQ ID NO:
- 45) and YIGSR (SEQ ID NO;
46), and (ii) a metal ion to induce gelation of said amphiphile compound whereby the composition forms a gel of supramolecular nanofibers of said amphiphile compound in the presence of said reagent, wherein said reagent comprises metal ion in stoichiometric excess of said amphiphile compound. - View Dependent Claims (2, 3, 4, 5)
- 45) and YIGSR (SEQ ID NO;
Specification