HMG-CoA reductase inhibitors and method
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Abstract
Compounds are provided having the following structure which are HMG CoA reductase inhibitors and thus are active in inhibiting cholesterol biosynthesis, modulating blood serum lipids, for example, lowering LDL cholesterol and/or increasing HDL cholesterol, and treating hyperlipidemia, dyslipidemia, hormone replacement therapy, hypercholsterolemia, hypertriglyceridemia and atherosclerosis as well as Alzheimer'"'"'s disease and osteoporosis
wherein X is N or CR5;
and pharmaceutically acceptable salts thereof,
wherein R1 to R7 are as defined herein.
A method for treating the above diseases employing the above compounds is also provided.
72 Citations
20 Claims
- 1. A compound of the formula
- 8. A compound having the structure
Specification