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Polypeptide variants with altered effector function

  • US 7,371,826 B2
  • Filed: 05/08/2006
  • Issued: 05/13/2008
  • Est. Priority Date: 01/15/1999
  • Status: Expired due to Term
First Claim
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1. An antibody comprising a variant human IgG1 Fc region which is not a native sequence Fc region, wherein the antibody comprises an amino acid substitution at amino acid position 434 of the Fc region, wherein the numbering of the residues in the Fc region is that of the EU index as in Kabat, and wherein the variant Fc region binds human neonatal Fc receptor (FcRn) with increased binding affinity compared to a native sequence human IgG1 Fc region.

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