Implantable device and method for treatment of hypertension

• US 7,373,204 B2
• Filed: 08/19/2004
• Issued: 05/13/2008
• Est. Priority Date: 08/19/2004
• Status: Active Grant

• Current Assignee: Lifestim, Inc.
• Original Assignee: Lifestim, Inc.
• Inventors: Levin, Howard R., Gelfand, Mark
• Primary Examiner(s): Layno; Carl
• Assistant Examiner(s): Heller; Tammie K.
• Application Number:
  US10/921,162
• Publication Number:
  US 20060041283A1
• Time in Patent Office: 1,363 Days
• Field of Search: 607/44, 607/2, 607/48, 128/907
• US Class Current: 607/44
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/36117 for treating hypertension
• CPC Class Codes: Y10S 128/907 Acupuncture

Abstract

A method and apparatus for treatment of hypertension with electrostimulation of peripheral nerves. Treatment is performed by periodically stimulating a nerve such as a median nerve. Apparatus for stimulation is permanently implanted in the body. The nerve is stimulated by electric current applied to electrodes that are placed near the target nerve or the muscle innervated by the target nerve.

Claims

1. A method for treating hypertension in a human patient comprising:

implanting a nerve stimulation device proximate to at least one peripheral nerve in an extremity of the patient, wherein the implanting is at least partially performed by inserting a lead into the fascia surrounding the nerve; and

applying a stimulation signal generated by the device to the peripheral nerve to control hypertension so as to avoid pain or twitching of a muscle in the extremity caused by the stimulation, the signal being applied repeatedly over a period of time to reduce blood pressure.

2. The method as in claim 1, wherein the peripheral nerve is one of a group consisting of a median nerve, a peroneal nerve, and deep peroneal nerve.

3. The method as in claim 1, wherein the stimulation signal further comprises electric pulses having a frequency in a range of 1 to 5 Hz.

4. The method as in claim 1, wherein the stimulation signal is applied based on a physiologic feedback.

5. The method as in claim 1, wherein the stimulation device is implanted on a surface of a muscle innervated by the peripheral nerve.

6. The method as in claim 1, wherein the stimulation device is implanted along the peripheral nerve.

7. The method as in claim 1, wherein the stimulation device is implanted proximally to a Neiguan point or points Tianchi, Tianguan, Quze, Ximen, Jianshi, Daling, Laogong, and Zhonghong in an arm of the patient.

8. The method as in claim 1, wherein the stimulation device is implanted proximally to a Zusanli point in a leg of the patient.

9. The method as in claim 1, wherein the stimulation signal is applied with electric pulses at a current of 0.5 to 5 mA and a duration of 0.25 to 0.5 ms;

and wherein the stimulation signal is applied for 20 to 60 minutes followed by a rest period.

10. A method for treating hypertension in a human patient comprising:

implanting a nerve stimulation device proximate to a median nerve in a wrist of the patient, wherein the implanting is at least partially performed by inserting a lead between tendons of the wrist in proximity to the nerve; and

applying a stimulation signal generated by the device to the peripheral nerve to control hypertension so as to avoid pain or twitching of a muscle in the extremity caused by the stimulation, the signal being applied repeatedly over a period of time to reduce blood pressure.

11. The method as in claim 10, wherein the stimulation signal further comprises electric pulses having a frequency in a range of 1 to 5 Hz.

12. The method as in claim 10, wherein the stimulation signal is applied based on a physiologic feedback.

13. The method as in claim 10, wherein the stimulation device is implanted on a surface of a muscle innervated by the median nerve.

14. The method as in claim 10, wherein the stimulation device is implanted along the median nerve.

15. The method as in claim 10, wherein the stimulation signal is applied with electric pulses at a current of 0.5 to 5 mA and a duration of 0.25 to 0.5 ms;

and wherein the stimulation signal is applied for 20 to 60 minutes followed by a rest period.