System for determining endothelial dependent vasoactivity
First Claim
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1. A method of determining endothelial dependent vasoactivity of a subject, the method comprising:
- recording pressure-related signals of a plurality of locations adjacent to at least one blood vessel;
extracting parameters from said pressure-related signals, said parameters comprise a first parameter, sensitive to arterial radius changes at the initial stage of arterial dilatation, and a second parameter, sensitive to arterial radius changes at larger arterial dilatation;
using said parameters to determine a change of at least one characteristic of said at least one blood vessel, said change being representative of endothelial functioning;
determining the endothelial dependent vasoactivity of the subject using said parameters; and
displaying at least an indication of said endothelial dependent vasoactivity.
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Abstract
A method of determining endothelial dependent vasoactivity of a subject, the method is effected by recording pressure-related signals of a plurality of locations adjacent to at least one blood vessel; extracting at least one parameter from the pressure-related signals; and using the at least one parameter to determine a change of at least one characteristic of the at least one blood vessel, the change being representative of endothelial functioning; thereby determining the endothelial dependent vasoactivity of the subject.
25 Citations
59 Claims
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1. A method of determining endothelial dependent vasoactivity of a subject, the method comprising:
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recording pressure-related signals of a plurality of locations adjacent to at least one blood vessel; extracting parameters from said pressure-related signals, said parameters comprise a first parameter, sensitive to arterial radius changes at the initial stage of arterial dilatation, and a second parameter, sensitive to arterial radius changes at larger arterial dilatation; using said parameters to determine a change of at least one characteristic of said at least one blood vessel, said change being representative of endothelial functioning; determining the endothelial dependent vasoactivity of the subject using said parameters; and displaying at least an indication of said endothelial dependent vasoactivity. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. A system for determining endothelial dependent vasoactivity of a subject, the system comprising:
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an arrangement of sensors for recording pressure-related signals of a plurality of locations adjacent to at least one blood vessel; a processing unit operable to receive, record and process said pressure-related signals and configured to display results of said processing; said processing unit being designed and programmed to extract parameters from said pressure-related signals, and to use said parameters to determine a change of at least one characteristic of said at least one blood vessel, said change being representative of endothelial functioning, wherein the parameters extracted from the pressure-related signals comprise a first parameter, sensitive to arterial radius changes at the initial stage of arterial dilatation, and a second parameter, sensitive to arterial radius changes at larger arterial dilatation. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49)
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50. A method of determining endothelial dependent vasoactivity of a subject, the method comprising:
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(a) applying a first stimulus to at least one blood vessel; (b) measuring a pulse wave velocity of blood flowing in said at least one blood vessel; (c) determining an autonomic nervous system activity of the subject; (d) correlating said pulse wave velocity and said autonomic nervous system activity, so as to obtain a correlation function having an index; (e) if said index has a predetermined value then; (i) applying a second stimulus on said at least one blood vessel; and (ii) repeating said steps (b)-(c); and
thereby determining the endothelial dependent vasoactivity of the subject; and(f) displaying at least an indication of the endothelial dependent vasoactivity of the subject, wherein said step (e) further comprises applying said second stimulus on at least one additional blood vessel and repeating said steps (b)-(c) for said at least one additional blood vessel. - View Dependent Claims (51, 52, 53, 54, 55, 56, 57, 58)
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59. A method of determining endothelial dependent vasoactivity of a subject, the method comprising:
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(a) applying a first stimulus to at least one blood vessel; (b) measuring a pulse wave velocity of blood flowing in said at least one blood vessel; (c) determining an autonomic nervous system activity of the subject; (d) correlating said pulse wave velocity and said autonomic nervous system activity, so as to obtain a correlation function having an index; (e) if said index has a predetermined value then; (i) applying a second stimulus on said at least one blood vessel; and (ii) repeating said steps (b)-(c); and
thereby determining the endothelial dependent vasoactivity of the subject; and(f) displaying at least an indication of the endothelial dependent vasoactivity of the subject, wherein said first and said second stimuli are each independently selected from the group consisting of a stimulus, a thermal stimulus, a chemical stimulus, an electrical stimulus, a mental stress stimulus and a physical exercise stimulus.
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Specification