Delivery device for an acidity monitoring system

• US 7,374,547 B2
• Filed: 04/25/2003
• Issued: 05/20/2008
• Est. Priority Date: 04/25/2003
• Status: Expired due to Fees

• Current Assignee: Given Imaging Limited (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Eerdmans, Pedro H. A.
• Primary Examiner(s): Hindenburg; Max F.
• Assistant Examiner(s): TOWA, RENE T
• Application Number:
  US10/424,550
• Publication Number:
  US 20040215128A1
• Time in Patent Office: 1,852 Days
• Field of Search: 600/350, 600/361, 600/587, 600/593, 600/309, 600/561, 600/407, 600301-302, 600/476, 600/101, 600/104, 600/106, 600/109, 600114-117, 600/143, 600/151, 600/160
• US Class Current: 600/593
• CPC Class Codes: A61B 5/037 Measuring oesophageal pressure
• CPC Class Codes: A61B 5/073 Intestinal transmitters
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/4211 Diagnosing or evaluating reflux
• CPC Class Codes: A61B 5/4233 oesophagus
• CPC Class Codes: A61B 5/6882 Anchoring means

Abstract

The invention is directed to techniques for delivering a capsule for sensing acidity to a location along the esophagus via a delivery device that detects pressure variations to identify a lower esophageal sphincter (LES). More specifically, the distal end of a probe of the delivery device enters the esophagus, and extends through the esophagus into the stomach via the LES. The distal end of the probe is slowly retracted back into the esophagus and the pressure variation within a pressure sensitive chamber of the delivery device, caused by the LES, is detected to identify the location of the LES. As described, the pressure sensitive chamber can comprise a balloon filled with air or an airtight chamber formed within a distal end of the probe. In either case, the pressure sensitive chamber deforms due to the pressure of the LES thereby causing a pressure variation used to identify the location of the LES.

Claims

1. A device for identifying a location within a patient for delivery of a capsule, the device comprising:

a probe that defines an inner lumen;

a capsule detachably coupled to a distal end of the probe that includes a sensor;

a pressure sensitive chamber within the inner lumen of the probe;

a vacuum inlet at a proximal end of the probe that couples with a vacuum source;

a vacuum outlet located at the distal end of the probe;

a membrane that covers the vacuum outlet; and

a pressure sensor to detect pressure variation within the pressure sensitive chamber indicative of proximity to a sphincter within the patient to identify a location for delivery of the capsule, wherein the vacuum inlet, when closed, forms the pressure sensitive chamber within the inner lumen of the probe, and the vacuum inlet, when opened, permits application of suction from the vacuum source within the inner lumen of the probe in order to remove or rupture the membrane that covers the vacuum outlet.

2. The device of claim 1, wherein the membrane is formed from a flexible material and deforms due to outside pressure changes to cause a pressure variation within the pressure sensitive chamber.

3. The device of claim 1, further comprising a balloon that expands to form the pressure sensitive chamber.

4. The device of claim 1, further comprising a display at a proximal end of the device to display the pressure variations detected by the pressure sensor.

5. The device of claim 4, wherein the display comprises one of a liquid crystal display (LCD) and a light emitting diodes (LED) display.

6. The device of claim 1, wherein the capsule defines a void and the vacuum source provides suction to the vacuum outlet to draw a portion of esophageal tissue into the void of the capsule, further comprising an anchor mechanism to penetrate the portion of esophageal tissue in the void of the capsule in order to anchor the capsule to the esophageal tissue.

7. The device of claim 6, wherein the anchor mechanism comprises a locking pin that advances through the esophageal tissue to anchor the capsule to the esophageal tissue.

8. The device of claim 1, further comprising a switch to switch the pressure sensor on.

9. The device of claim 1, further comprising a valve that opens and closes the vacuum inlet of the device.

10. The device of claim 1, wherein the sensor comprises an acidity sensor to detect the acidity of a surrounding location.

11. A method for delivering a capsule within a patient, the method comprising:

inserting at least a portion of a probe into the patient;

forming a pressure sensitive chamber within the probe for detecting pressure variations within the patient, wherein the probe has a vacuum outlet and a vacuum inlet, the vacuum outlet being covered by a membrane, and wherein forming the pressure sensitive chamber comprises closing the vacuum inlet;

detecting pressure variation within the pressure sensitive chamber of the probe, said pressure variation being indicative of proximity to a sphincter of the patient, opening the vacuum inlet to provide suction within the probe;

removing or rupturing the membrane that covers the vacuum outlet via the suction;

providing the suction to a tissue site of the patient to draw a portion of the tissue site into a void of a capsule coupled to a distal end of the probe in response to detecting the pressure variation indicative of proximity to the sphincter;

anchoring the capsule to the tissue site; and

detaching the capsule from the probe.

12. The method of claim 11, wherein the capsule includes a sensor and further comprising:

measuring at least one parameter of the tissue site via the sensor of the capsule; and

transmitting the measured parameters from the capsule to a receiver.

13. The method of claim 12, wherein the sensor comprises an acidity sensor and the parameter comprises pH information.

14. The method of claim 11, wherein the membrane is formed from a flexible material and deforms due to outside pressure changes to cause the detected pressure variation.

15. The method of claim 11, wherein forming a pressure sensitive chamber comprises filling a balloon with air to form the pressure sensitive chamber.

16. The method of claim 15, wherein the balloon deforms due to outside pressure changes to cause the detected pressure variation.

17. The method of claim 11, further comprising displaying the pressure variation to a user.

18. The method of claim 11, wherein detecting a pressure variation within a pressure sensitive chamber comprises detecting a pressure variation due to transitioning from a stomach to an esophagus via a lower esophageal sphincter (LES).

19. The method of claim 11, wherein anchoring the capsule to the tissue site comprises advancing a locking pin through the portion of the tissue site in the void of the capsule.

20. The method of claim 11, wherein the tissue site comprises the esophagus.