Production of microspheres
First Claim
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1. A process for preparing microspheres comprising the steps ofcombining a macromolecule and a polymer in an aqueous solution, wherein the polymer is water soluble or soluble in a water miscible solvent,contacting a volume of the aqueous solution with a surface at a surface area to volume ratio of at least about 6.5 cm−
- 1,heating the aqueous solution, andforming the microspheres continuously in the aqueous solution in a continuous process.
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Abstract
Protein microspheres are produced by contacting an aqueous solution of a macromolecule and a polymer with a surface at a high surface area to volume ratio, and heating the solution. The microspheres are useful for preparing pharmaceuticals of defined dimensions which can be delivered to a patient by inhalation therapy.
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36 Claims
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1. A process for preparing microspheres comprising the steps of
combining a macromolecule and a polymer in an aqueous solution, wherein the polymer is water soluble or soluble in a water miscible solvent, contacting a volume of the aqueous solution with a surface at a surface area to volume ratio of at least about 6.5 cm− - 1,
heating the aqueous solution, and forming the microspheres continuously in the aqueous solution in a continuous process. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
- 1,
Specification