Systems and methods for removing viral agents from blood

• US 7,374,870 B2
• Filed: 02/11/2005
• Issued: 05/20/2008
• Est. Priority Date: 10/28/1996
• Status: Expired due to Fees

• Current Assignee: Fenwal Incorporated (Fresenius SE & Co. KGaA)
• Original Assignee: Fenwal Incorporated (Fresenius SE & Co. KGaA)
• Inventors: Chapman, John, Mathias, Jean M, Herman, Robert E., Sun, Chong-Son, Bischof, Daniel F.
• Primary Examiner(s): Saucier; Sandra E.
• Application Number:
  US11/056,347
• Publication Number:
  US 20050186553A1
• Time in Patent Office: 1,194 Days
• Field of Search: None
• US Class Current: 435/2
• CPC Class Codes: A61K 35/16 Blood plasma; Blood serum umbilical cord blood A61K35/51
• CPC Class Codes: A61L 2/0011 using physical methods
• CPC Class Codes: A61L 2/022 Filtration
• CPC Class Codes: A61L 2/08 Radiation
• CPC Class Codes: Y10S 435/975 Kit

Abstract

Systems and methods treat plasma carrying contaminants and cellular matter that are capable of entraining contaminants. The systems and methods separate cellular matter from the plasma by filtration, thereby removing contaminants entrained within the cellular matter. The system and methods add to the plasma a photoactive material. The systems and methods emit radiation at a selected wavelength into the plasma to activate the photoactive material and thereby eradicate the contaminant that is free of entrainment by cellular matter.

Claims

1. A method for treating a plasma carrying contaminants and cellular matter capable of entraining contaminants, the method comprising the steps of

conveying plasma through a first path through a filter that separates cellular matter from the plasma, thereby removing contaminants entrained within the cellular matter,

conveying the plasma from the filter through a second path that includes an attached transfer container,

mixing within the transfer container the plasma with a photoactive material to form a plasma mixture,

conveying a portion of the plasma mixture from the transfer container through a flush path that includes the second path to thereby expose contaminants in the second path to the photoactive material,

severing the second path to separate the transfer container from the filter, the transfer container, after severance from the filter, carrying a remnant of the second path, and

emitting radiation into the transfer container at a selected wavelength to activate the photoactive material in the plasma mixture and thereby eradicate the contaminant that is free of entrainment by cellular matter.

2. A method according to claim 1 wherein the flush path by passes the filter.

3. A method according to claim 1 and further including the step of venting air from the transfer container through the flush path.

4. A method according to claim 3 wherein the flush path by passes the filter.

5. A method according to claim 1 and further including the step of storing the plasma mixture in the transfer container after the radiation emitting step.