Human kinases and polynucleotides encoding the same, and uses thereof

• US 7,374,932 B2
• Filed: 12/29/2004
• Issued: 05/20/2008
• Est. Priority Date: 05/19/2000
• Status: Expired due to Term

• Current Assignee: Lexicon Pharmaceuticals, Inc. (The Invus Group LLC)
• Original Assignee: Lexicon Pharmaceuticals, Inc. (The Invus Group LLC)
• Inventors: Hilbun, Erin, Van Sligtenhorst, Isaac, Hansen, Gwenn, Donoho, Gregory, BeltrandelRio, Hector, Walke, D. Wade, Turner, C. Alexander Jr.
• Primary Examiner(s): Monshipouri; Maryam
• Application Number:
  US11/025,671
• Publication Number:
  US 20070270506A1
• Time in Patent Office: 1,238 Days
• Field of Search: 536/23.2, 435/252.3, 435/320.1, 435/194
• US Class Current: 435/320.1
• CPC Class Codes: A01K 2207/15 Humanized animals
• CPC Class Codes: A01K 2217/00 Genetically modified animals
• CPC Class Codes: A01K 2217/075 inducing loss of function, i.e. knock out
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61P 13/12 of the kidneys
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: A61P 9/12 Antihypertensives
• CPC Class Codes: C12N 9/12 transferring phosphorus containing groups, e.g. kinases (2.7)
• CPC Class Codes: C12N 9/1205 Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases

Abstract

Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.

Claims

1. An isolated nucleic acid molecule comprising a nucleotide sequence encoding the amino acid sequence shown in SEQ ID NO:

2.

3. A recombinant expression vector comprising the isolated nucleic acid molecule of claim 1.

4. The recombinant expression vector of claim 3, wherein said nucleic acid molecule comprises the nucleotide sequence of SEQ ID NO:

1.

5. A host cell comprising the recombinant expression vector of claim 3.

2. An isolated nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:

1.