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Pharmaceutical compositions for prevention of overdose or abuse

  • US 7,375,083 B2
  • Filed: 09/30/2004
  • Issued: 05/20/2008
  • Est. Priority Date: 09/30/2003
  • Status: Active Grant
First Claim
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1. A method for altering the short term bioavailability of an oral dosage form of a hydromorphone composition comprising:

  • covalently bonding hydromorphone or a pharmaceutically acceptable salt thereof through the 2′

    or 6′

    position to the C-terminus of a single amino acid or an oligopeptide of 15 or fewer amino acids such that the hydromorphone does not release into a patient'"'"'s bloodstream at levels that give rise to a euphoric or overdose level.

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