Reagent injection device

• US 7,377,910 B2
• Filed: 03/04/2004
• Issued: 05/27/2008
• Est. Priority Date: 03/06/2003
• Status: Active Grant

• Current Assignee: Asahi Intecc Company Limited, Osamu Katoh
• Original Assignee: Asahi Intecc Company Limited, Osamu Katoh
• Inventors: Kato, Tomihisa, Katoh, Osamu, Momota, Masashi
• Primary Examiner(s): Lucchesi; Nicholas D.
• Assistant Examiner(s): KOHARSKI, CHRISTOPHER
• Application Number:
  US10/793,351
• Publication Number:
  US 20040176726A1
• Time in Patent Office: 1,545 Days
• Field of Search: 604/190, 604/164.01, 604/164.06, 604/164.13, 604/164.12, 604/166.01, 604/170.03, 604/170.02, 604/101.05, 604/272, 604/96.01
• US Class Current: 604/164.13
• CPC Class Codes: A61M 2025/009 the needle having a bent tip, i.e. the needle distal tip is angled in relation to the longitudinal axis of the catheter
• CPC Class Codes: A61M 25/0084 being one or more injection needles

Abstract

Embodiments of the present invention relate to an injection devices that inject a specified reagent with cells into lesions and other areas of body tissue. Particular embodiments comprise a main tube with a projection hole on its exterior, an axially-moveable needle tube with a needle at its tip, a reagent supplier configured to supply a specified reagent into the needle tube, and axially-moveable guide wires.

Claims

1. A reagent injection device comprising:

a flexible main tube, which is insertable into a body, said main tube comprising first, second, and third lumens provided therein, said third lumen being disposed closer to an axial center of the main tube than are the first and second lumens;

a first guide wire that is insertable into the main tube through the first lumen and which is configured to guide the first guide wire to move back and forth by extending out of the main tube at a first position in an axial direction of the main tube;

a second guide wire that is insertable into the main tube through the second lumen which is configured to guide the second guide wire to move back and forth by extending out of the main tube at a second position in a direction away from the first guide wire, wherein the first guide wire and the second guide wire are extendable from the main tube on a common plane with reference to the extended first guide wire and the extended second guide wire, said common plane being formed by the extended first guide wire and the extended second guide wire and extending through the extended first guide wire, the extended second guide wire, and the main tube; and

a needle tube that is insertable into the main tube through the third lumen and which is configured to guide the needle tube to move back and forth by projecting from the main tube at a third position in a direction substantially or nearly orthogonal to the common plane and away from the common plane by using the first and second guide wires on the common plane as a support structure, said third position being disposed between the first position and the second position in the axial direction of the main tube,

wherein the main tube further comprises an expandable and/or shrinkable balloon attached to its exterior, and a fourth lumen that supplies fluid for expanding the balloon is further provided inside of the main tube such that the center of the projection hole is positioned in the same plane that includes the center axis of the fourth lumen and the center axis of the main tube.

2. A reagent injection device as described in claim 1, wherein

the first lumen opens to the outside through a tip aperture of the main tube which is the first position;

the second lumen opens to the outside through a side hole which is the second position; and

the third lumen opens to the outside through a projection hole which is the third position, wherein the first guide wire is inserted into the first lumen, the second guide wire is inserted into the second lumen, and the needle tube is inserted into the third lumen in a manner that allows axial movement.

3. A reagent injection device as described in claim 2, wherein the first lumen opens to the side through an insertion hole provided in the tubular wall at the rear end of the main tube as viewed in the direction of its insertion into the body, wherein the first guide wire is inserted into the first lumen through the insertion hole, the second lumen opens to the rear through a rear-end aperture at the rear of the main tube, and the second guide wire is inserted into the second lumen through the rear-end aperture.

4. A reagent injection device as described in claim 2, wherein the first and second lumens are provided inside of the main tube such that the plane that includes the center axes of the lumens lies orthogonal to the opening direction of the projection hole.

5. A reagent injection device as described in claim 2, wherein the third lumen is provided inside the main tube such that the center of the projection hole is positioned in the plane that includes the center axis of the third lumen and the center axis of the main tube.

6. A reagent injection device as described in claim 2, wherein the third lumen is provided inside the main tube such that its center axis corresponds to the center axis of the main tube, and wherein the first and second lumens are provided inside the main tube on both sides of the third lumen such that their center axes are positioned in the same plane that includes the center axis of the third lumen.

7. A reagent injection device as described in claim 1, wherein the main tube further comprises a guide surface that guides the needle into the projection hole by means of sliding contact made by the needle along with the axial movement of the needle tube, wherein the guide surface comprises a convex curve that curves in the opening direction of the projection hole toward the front of the main tube as viewed in the direction of its insertion into the body.

8. A reagent injection device as described in claim 7;

wherein the needle comprises a curve corresponding to the curved guide surface, and wherein the needle tube is caused to deform in a manner creating a deeper curve by combining the convex curved shape of the guide surface and the curved shape of the needle.

9. The reagent injection device as described in claim 1, further comprising a reagent supplier configured to supply reagent through the needle tube.

10. A method of injecting a reagent into a human body, comprising:

inserting into a human body a tubular body which comprises a main tube and a projection hole on its exterior, said main tube comprising first, second, and third lumens provided therein, said third lumen being communicated with the projection hole and disposed closer to an axial center of the main tube than are the first and second lumens;

inserting an axially-moveable first guide wire into the main tube through the first lumen, wherein the first guide wire extends through a tip aperture provided at the front of the main tube as viewed in the direction of its insertion into the body;

inserting an axially moveable second guide wire into the main tube through the second lumen, wherein the second guide wire extends through a side hole that opens in a direction such that the first and second guide wires are extended from the main tube on a common plane with reference to the extended first guide wire and the extended second guide wire, said common plane being formed by the extended first guide wire and the extend second guide wire, extending through the extended first guide wire, the extended second guide wire, and the main tube, and being substantially or nearly orthogonal to an opening direction of the projection hole which is disposed between the tip aperture and the side hole in an axial direction of the main tube;

inserting an axially-moveable needle into the main tube through the third lumen;

guiding the needle to a tissue in the body with the first and second guide wires;

projecting the needle through the projection hole and into the tissue in a direction substantially or nearly orthogonal to the common plane and away from the common plane by using the first and second guide wires on the common plane as a support structure;

supplying a specified reagent into the needle tube; and

injecting reagent into the tissue.

11. A reagent injection device for injecting a reagent into a human body, comprising:

a tubular body configured to be inserted into a human body and comprising a main tube having (a) a tip aperture provided at a distal end, (b) a projection hole provided on a side, and (c) a side hole provided on a side, wherein the projection hole is disposed between the tip aperture and the side hole in an axial direction of the main tube, said main tube comprising a first lumen communicated with the tip aperture, a second lumen communicated with the side hole, and a third lumens communicated with the projection hole and disposed closer to an axial center of the main tube than are the first and second lumens;

an axially-moveable first guide wire that is inserted into the tubular body through the first lumen and that is configured to extend through the tip aperture in an axial direction of the tubular body; and

an axially-moveable second guide wire that is inserted into the tubular body through the second lumen and that is configured to extend through the side hole in a direction such that when the first and the second guide wires extend, the first and the second guide wires define a common plane with reference to the extended first guide wire and the extended second guide wire, said common plane being formed by the extended first guide wire and the extended second guide wire and extending through the extended first guide wire, the second extended guide wire, and the main tube;

an axially-moveable needle tube for injecting a reagent which is formed with a thin flexible tube, wherein the needle tube is inserted into the tubular body through the third lumen and is configured to project through the projection hole in a direction substantially or nearly orthogonal to the common plane,

wherein when the tubular body is inserted into the body, the needle projects through the projection hole and pierces tissue in the body in the direction substantially or nearly orthogonal to the common plane and away from the common plane by using the first and second guide wires on the common plane as a support structure, and a reagent can be supplied through the needle tube and injected into the tissue.

12. The reagent injection device according to claim 11, wherein the tubular body is provided with a marker in the vicinity of the projection hole, which marker is made of a radiopaque material.

13. The reagent injection device according to claim 11, wherein the tubular body has a curved guide surface that leads the needle to the projection hole when the needle is inserted into the tubular body, said curved guide surface being configured to guide the needle to project from the projection hole at an angle of no less than about 45°

but less than about 90°

with respect to the axis of the tubular body to allow the tip of the needle to extend in a direction generally orthogonal to the plane.

14. The reagent injection device according to claim 11, wherein the first lumen and the second lumen are generally parallel to each other in the tubular body.

15. The reagent injection device according to claim 14, wherein the first and the second lumens are arranged in the tubular body to maximize a distance between an axis of the first lumen and an axis of the second lumen.

16. The reagent injection device as described in claim 11, further comprising a reagent supplier configured to supply reagent through the needle tube.