Reusable, spring driven autoinjector

• US 7,381,201 B2
• Filed: 06/24/2003
• Issued: 06/03/2008
• Est. Priority Date: 06/24/2002
• Status: Expired due to Fees

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Gilbert, Scott, de la Sema, Pedro
• Primary Examiner(s): MENDEZ, MANUEL A
• Application Number:
  US10/603,513
• Publication Number:
  US 20040019326A1
• Time in Patent Office: 1,806 Days
• Field of Search: 604/209, 604/117, 604/196, 604/187, 604/232, 604/134, 604/208, 604/211, 604/192, 604/218, 604/220, 604/224, 604/228, 604/136, 604/138, 604/156, 604/157, 604/181
• US Class Current: 604/181
• CPC Class Codes: A61M 2005/206 With automatic needle insertion
• CPC Class Codes: A61M 2005/2418 comprising means for damping shocks on ampoule
• CPC Class Codes: A61M 2205/0266 Shape memory materials
• CPC Class Codes: A61M 5/2033 Spring-loaded one-shot injectors with or without automatic needle insertion multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287

Abstract

The present invention provides a reusable spring driven autoinjector. The drive mechanism of the autoinjector of the present invention includes one or more drive springs formed of a shape memory alloy. Therefore, by alternating the shape memory alloy forming the one or more drive springs between austenite phase before an injection and a martensite phase after injection, the reusable autoinjector of the present invention is capable of providing an injection force that is higher than the compressive force required to cock the drive mechanism in preparation for a subsequent injection operation.

Claims

1. An autoinjector comprising:

a housing;

a reservoir for containing a medicament in a distal portion of the housing;

a needle for delivering the medicament;

a drive mechanism in a proximal portion of the housing, the drive mechanism being capable of exerting a force sufficient to expel the medicament from the reservoir through the needle, the drive mechanism comprising a shape memory alloy drive spring, the shape memory alloy drive spring being formulated to exert a first force when in a martensite phase and a second force, which is larger than the first force, when in an austenite phase, the drive mechanism being capable of being manually re-cocked when the shape memory alloy drive spring is in the martensite phase.

2. The autoinjector of claim 1, wherein the first force is at least 20% less than the second force.

3. The autoinjector of claim 1, wherein the first force is at least 30% less than the second force.

4. The autoinjector of claim 1, wherein the first force is at least 40% less than the second force.

5. The autoinjector of claim 1, wherein the first force is at least 50% less than the second force.

6. The autoinjector of claim 1, wherein the shape memory alloy drive spring is formulated to provide a shape memory mode of behavior within an operational temperature range of the autoinjector.

7. The autoinjector of claim 1, wherein the shape memory alloy drive spring is fabricated of a shape memory alloy that is in an austenite phase within an ambient temperature range of an environment of use of the autoinjector.

8. The autoinjector of claim 7, wherein the ambient temperature range of the environment of use is about 20°

C. to about 25°

C.

9. The autoinjector of claim 8, wherein the shape memory alloy drive spring is fabricated using a shape memory alloy that is in a martensite phase at a temperature that is at or above about 4°

C.

10. The autoinjector of claim 1, wherein the shape memory alloy drive spring is fabricated of a shape memory alloy that is in a martensite phase within an ambient temperature range of an environment of use of the autoinjector.

11. The autoinjector of claim 10, wherein the ambient temperature range of the environment of use is about 20°

C. to about 25°

C.

12. The autoinjector of claim 11, wherein the shape memory alloy drive spring is fabricated using a shape memory alloy that is in an austenite phase at or above about 37°

C.

13. The autoinjector of claim 1, wherein the shape memory alloy drive spring is formed of a shape memory alloy formulated to achieve a full austenite phase and a full martensite phase within an operational temperature range of the autoinjector.

14. The autoinjector of claim 13, wherein the operational temperature range of the autoinjector is from about 4°

C. to about 37°

C.

15. The autoinjector of claim 1, wherein the shape memory alloy drive is a coiled wave spring.