Methods of treating diabetes mellitus
First Claim
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1. A method of treating diabetes mellitus in a patient in need of such treatment, said method comprising:
- orally administering an effective amount of an insulin polypeptide derivative to the patient within one hour of ingestion of a meal by the patient in order to treat diabetes mellitus in the patient, wherein the insulin polypeptide derivative has the following formula;
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Abstract
Methods of treating diabetes mellitus in a patient in need of such treatment include administering an effective amount of an insulin drug to the patient in order to treat diabetes mellitus in the patient. Methods according to the present invention may “activate” the liver, potentially restoring normal glucose homeostasis to individuals suffering from diabetes mellitus.
191 Citations
20 Claims
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1. A method of treating diabetes mellitus in a patient in need of such treatment, said method comprising:
orally administering an effective amount of an insulin polypeptide derivative to the patient within one hour of ingestion of a meal by the patient in order to treat diabetes mellitus in the patient, wherein the insulin polypeptide derivative has the following formula; - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A method of treating diabetes mellitus in a patient in need of such treatment, said method comprising:
orally administering an effective amount of an insulin polypeptide derivative to the patient in order to treat diabetes mellitus in the patient, wherein the insulin polypeptide derivative has the following formula;
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17. A method of treating diabetes mellitus in a patient in need of such treatment, said method comprising:
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orally administering an effective amount of an insulin polypeptide derivative to the patient in order to treat diabetes mellitus in the patient, wherein the insulin polypeptide derivative has the following formula; and wherein the effective amount of the insulin polypeptide derivative is administered so that it stabilizes peripheral glucose concentration to within +/−
50 percent of an average peripheral glucose concentration measured over about a one hour time period beginning about 30 minutes after administration.
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18. A method of treating diabetes mellitus in a patient in need of such treatment, said method comprising:
orally administering an effective amount of an insulin polypeptide derivative to the patient in order to treat diabetes mellitus in the patient, wherein the insulin polypeptide derivative has the following formula; - View Dependent Claims (19)
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20. A method of treating diabetes mellitus in a patient in need of such treatment, said method comprising:
orally administering an effective amount of an insulin polypeptide derivative to the patient in order to treat diabetes mellitus in the patient, wherein the insulin polypeptide derivative has the following formula;
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