Antimicrobial composition for medical articles
First Claim
1. An article having an antimicrobial coating made by(A) applying to an uncoated article an antimicrobial composition that comprises(1) about 5 to about 25 wt % of an antimicrobial formulation that comprises(a) about 40 to about 65 wt % of an antimicrobial material;
- (b) about 1 to about 55 wt % calcium chelator;
(c) about 0.00 1 to about 0.25 wt % pigment; and
(d) about 0.5 to about 5 wt % polyethylene oxide; and
(2) about 75 to about 95 wt % of a silicone resin; and
(3) an optional non-toxic organic solvent; and
(B) permitting said coating to form on said uncoated article, whereby said antimicrobial material leaches from said antimicrobial formulation, keeping the surface of said coating free of live bacteria, yeasts, and molds.
1 Assignment
0 Petitions
Accused Products
Abstract
An antimicrobial composition is formed from about 5 to about 25 wt % of an antimicrobial formulation and about 75 to about 95 wt % of a silicone resin. The antimicrobial formulation is formed from about 60 to about 95 wt % of an antimicrobial material, about 1 to about 30 wt % calcium chelator, about 0.001 to about 0.25 wt % pigment, and about 0.5 to about 3.5 wt % lubricant. The silicone resin may be a dispersion of about 40 to about 60 w/v % of an RTV silicone resin in a solvent, a liquid silicone resin, or a solid silicone resin. An antimicrobial coating may be formed on the surface of an article by applying an antimicrobial composition to the article and permitting the solvent to evaporate. It may also be formed by making a mixture of about 5 to about 12 wt % of an antimicrobial formulation and about 88 to about 95 wt % of a liquid or solid silicone resin and molding, overmolding, or extruding the article from the compounded mixture.
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Citations
22 Claims
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1. An article having an antimicrobial coating made by
(A) applying to an uncoated article an antimicrobial composition that comprises (1) about 5 to about 25 wt % of an antimicrobial formulation that comprises (a) about 40 to about 65 wt % of an antimicrobial material; -
(b) about 1 to about 55 wt % calcium chelator; (c) about 0.00 1 to about 0.25 wt % pigment; and (d) about 0.5 to about 5 wt % polyethylene oxide; and (2) about 75 to about 95 wt % of a silicone resin; and (3) an optional non-toxic organic solvent; and (B) permitting said coating to form on said uncoated article, whereby said antimicrobial material leaches from said antimicrobial formulation, keeping the surface of said coating free of live bacteria, yeasts, and molds. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 18, 19)
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17. A Foley catheter having an antimicrobial coating made by
(A) applying to an uncoated catheter an antimicrobial composition that comprises (1) about 5 to about 1 wt % of an antimicrobial formulation that comprises (a) about 15 to about 1 wt % of an antimicrobial material that includes silver, copper, and parabenzoic acid esters; -
(b) about 20 to about 1 wt % citric acid and about 20 to about 1 wt % ethylene diamine tetraacetic acid; (c) about 0.1 to about 0.1 wt % pigment; (d) about 4 to about 5 wt % polyethylene oxide; and (e) about 0 to about 4 wt % titanium dioxide; and (2) about 88 to about 95 wt % of a dispersion of about 40 to about 60 w/v % of an RTV silicone in a solvent selected from the group consisting of hexanes, methyl ethyl ketone, and xylenes whereby said antimicrobial material slowly leaches from said antimicrobial formulation, keeping the surface of said coating free of live bacteria, yeasts, and molds.
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20. A Foley catheter having an antimicrobial coating made by applying to an uncoated catheter an antimicrobial composition that comprises
(1) about 5 to about 12 wt % of an antimicrobial formulation that comprises (a) about 15 to about 1 wt % of an antimicrobial material that includes silver, copper, and parabenzoic acid esters; -
(b) about 20 to about 1 wt % citric acid and about 20 to about 1 wt % ethylene diamine tetraacetic acid; (c) about 0.005 to about 0.01 wt % pigment; (d) about 2 to about 5 wt % polyethylene oxide; and (e) about 0 to about 4 wt % titanium dioxide; and (2) about 88 to about 95 wt % of a liquid silicone resin whereby said antimicrobial material leaches from said antimicrobial formulation, keeping the surface of said coating free of live bacteria, yeasts, and molds. - View Dependent Claims (21, 22)
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Specification