Microsensor system and method for measuring data

• US 7,383,071 B1
• Filed: 01/20/2004
• Issued: 06/03/2008
• Est. Priority Date: 04/25/2003
• Status: Expired due to Fees

• Current Assignee: Marvin Gaye, The Government Of The United States As Represented By The Secretary Of The Navy
• Original Assignee: the united states of america as represented by the secretary of the navy
• Inventors: Russell, Stephen D., Pugh, Jamie K., de la Houssaye, Paul R., Walker, Howard W., Pugh, William, Amundson, Dennis E.
• Primary Examiner(s): Nasser; Robert L
• Application Number:
  US10/762,133
• Time in Patent Office: 1,596 Days
• Field of Search: 600/302, 600/300, 600/301
• US Class Current: 600/345
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/1477 non-invasive

Abstract

One embodiment is a microprobe. An example of the microprobe comprises a housing having an aperture. This example of the microprobe also comprises an ISFET attached to the housing. The ISFET may have a gate located proximate the aperture. This example of the microprobe further comprises a reference electrode attached to the housing proximate the aperture. Another embodiment is a microsensor system. Another embodiment is a method for measuring a characteristic of tissue. Yet another condition embodiment is a method for monitoring tissue pH.

Claims

1. A microsensor system, comprising:

an actuator;

a microprobe proximate the actuator, wherein the microprobe comprises;

a housing having an aperture;

an ISFET attached to the housing, wherein the ISFET has a gate located proximate the aperture; and

a reference electrode attached to the housing proximate the aperture; and

a cantilever arm attached to the actuator and the microprobe.

2. The microsensor system of claim 1, wherein the actuator is a piezoelectric actuator.

3. The microsensor system of claim 1, wherein the actuator is an electromagnetic actuator.

4. The microsensor system of claim 1, wherein the microprobe is configured to be broken off of the cantilever arm once the microprobe is inserted into dermis.

5. The microsensor system of claim 1, wherein the microsensor system is flexible, such that the microsensor system is configured to conform to the skin of a patient.

6. A microprobe comprising:

a housing having an aperture;

an ion sensitive field effect transistor (ISFET) attached to the housing, wherein the ISFET has a gate located proximate the aperture;

a reference electrode attached to the housing proximate the aperture, wherein the housing is a hermetically sealed encapsulant that encapsulates the microprobe and exposes at least a portion of the gate and at least a portion of the reference electrode within the aperture, and wherein the ISFET is configured to operate as a pH sensor; and

a second ISFET, wherein the second ISFET is configured to operate as a blood gas sensor, and wherein the second ISFET has a gate located in communication with the aperture.

7. A microprobe, comprising:

a substrate;

an ion sensitive field effect transistor (ISFET) monolithically integrated to the substrate, wherein the ISFET comprises a gate, and wherein the ISFET is configured to operate as a pH sensor;

a reference electrode monolithically integrated to the substrate;

a second ISFET, monolithically integrated to the substrate, wherein the second ISFET comprises a second gate, and wherein the second ISFET is configured to operate as a blood gas sensor;

associated circuitry comprising a temperature sensing diode, wherein the associated circuitry is monolithically integrated with the substrate; and

a housing having an aperture, wherein the housing hermetically encapsulates the substrate, the ISFET, the second ISFET, the reference electrode, and the associated circuitry, and wherein at least a portion of the gate, the second gate, and the reference electrode are located within the aperture.

8. The microprobe of claim 7, further comprising an antenna and a capacitor, wherein the capacitor is electrically coupled to the ISFET, the second ISFET, the temperature sensing diode, and the antenna, and wherein the capacitor is configured to store electromagnetic energy received by the antenna.

9. The microprobe of claim 8, further comprising a control module communicatively coupled to the ISFET, the second ISFET, the temperature sensing diode and the reference electrode.

10. The microprobe of claim 9, wherein the control module is hand-held.

11. The microprobe of claim 9, further comprising an electromagnetic transmitter configured to wirelessly transmit data from the ISFET, the second ISFET, and the temperature sensing diode to the control module.

12. The microprobe of claim 11, wherein the associated circuitry further comprises a logic array configured to perform statistical algorithms on the data from the ISFET, the second ISFET, and the temperature sensing diode.