Mapping retinal function using corneal electrode array

• US 7,384,145 B2
• Filed: 02/15/2007
• Issued: 06/10/2008
• Est. Priority Date: 02/16/2006
• Status: Active Grant

• Current Assignee: Board of Trustees of The University of Illinois
• Original Assignee: Board of Trustees of The University of Illinois
• Inventors: Hetling, John R., Ban, Tamas, Rahmani, Safa
• Primary Examiner(s): Sugarman; Scott J.
• Assistant Examiner(s): PINKNEY, DAWAYNE
• Application Number:
  US11/707,783
• Publication Number:
  US 20070188710A1
• Time in Patent Office: 481 Days
• Field of Search: 351/205, 351/219, 351/221, 351/246
• US Class Current: 351/219
• CPC Class Codes: A61B 5/398 Electrooculography [EOG], e.g. detecting nystagmus; Electroretinography [ERG]

Abstract

A system and method for obtaining information about the spatial distribution of photoreceptor activity and neural activity in the retina using simultaneously recorded multiple biopotential signals. The information thus gathered is used to assess retinal dysfunction due to trauma or disease. The biopotential signals are recorded from the surface of the eye and head using a plurality of electrodes, including those integral to a contact lens. The biopotential signals are recorded before, during and after the presentation of an optical stimulus to the subject eye. The recorded biopotential signals are then analyzed and interpreted to reveal the distribution of photoreceptor activity and neural activity across the retina. The analysis and interpretation of the biopotential signals is quantitative, and makes use of an electromagnetic model of the subject eye. The subject may be animal or human.

Claims

1. An electrode array for electroretinography comprising:

a contact lens body having an outer periphery, an inner surface facing a patient'"'"'s eye and an opposing outer surface;

an array of a plurality of conductive members carried on the inner surface of the contact lens body so as to be integral therewith;

multiple groups of linear conductive members being positioned about the contact lens body with different groups pointing in different directions so that at least a portion of the conductive members contacts the patient'"'"'s cornea;

the array of conductive members being spaced apart from one another so as to be substantially transparent to full-field stimulation of the patient'"'"'s eye;

the conductive members extending to the outer periphery of the contact lens body; and

connections for electrically connecting the conductive members to electrical circuitry external to the electrode for monitoring the array of conductive members at multiple locations, simultaneously, for the distribution of electrical activity of the retina as recorded at multiple locations across the cornea in response to the full-field stimulation, each connection being provided at the outer periphery so as to be integral with the contact lens body.

2. The electrode array of claim 1 wherein the conductive members have different lengths.

3. The electrode array of claim 1 wherein the conductive members extending from the outer periphery, generally toward the center.

4. The electrode array of claim 1 wherein the conductive members are elongated and spaced apart sufficiently so as to avoid substantially impairing the patient'"'"'s vision.

5. An electrode array for electroretinography comprising:

a contact lens body having an outer periphery, an inner surface facing a patient'"'"'s eye and an opposing outer surface, with a plurality of concentric reference circles on the inner surface;

an array of a plurality of conductive members carried on the inner surface of the contact lens body so as to be integral therewith, pointing in different directions and extending to an inner one of the concentric circles so that at least a portion of the conductive members contacts the patient'"'"'s cornea;

a central conductive member carried on the inner surface of the contact lens body so as to be integral therewith, extending to the approximate center of the contact lens body;

the array of conductive members being spaced apart from one another so as to be substantially transparent to full-field stimulation of the patient'"'"'s eye;

the conductive members extending to the outer periphery of the contact lens body; and

connections for electrically connecting the conductive members to electrical circuitry external to the electrode for monitoring the array of conductive members at multiple locations, simultaneously, for the distribution of electrical activity of the retina as detected at multiple locations across the cornea in response to the full-field stimulation, each connection being provided at the outer periphery so as to be integral with the contact lens body.

6. The electrode array of claim 5 wherein the conductive members have different lengths.

7. The electrode array of claim 5 wherein the conductive members extending from the outer periphery, generally toward the center.

8. The electrode array of claim 5 wherein the conductive members are elongated and spaced apart sufficiently so as to avoid substantially impairing the patient'"'"'s vision.

9. An electrode array for electroretinography comprising:

a contact lens body having an outer periphery, an inner surface facing a patient'"'"'s eye and an opposing outer surface, with a plurality of concentric reference circles adjacent the outer periphery;

an array of a plurality of conductive members carried on the inner surface of the contact lens body so as to be integral therewith, including two pairs of part circular elements adjacent the outer periphery, extending away from one another, with the elements of each pair having a different length;

a central conductive member carried on the inner surface of the contact lens body so as to be integral therewith, extending to the approximate center of the contact lens body;

the array of conductive members and the central conductive member being spaced apart from one another so as to be substantially transparent to full-field stimulation of the patient'"'"'s eye; and

connections for electrically connecting the conductive members to electrical circuitry external to the electrode for monitoring the array of conductive members at multiple locations simultaneously for the distribution of electrical activity of the retina as observed at multiple locations across the cornea in response to the full-field stimulation, each connection being provided at the outer periphery so as to be integral with the contact lens body.

10. The electrode array of claim 9 wherein the conductive members have a uniform width.

11. The electrode array of claim 9 wherein the conductive members extending from the outer periphery, generally toward the center.

12. The electrode array of claim 9 wherein the conductive members are elongated and spaced apart sufficiently so as to avoid substantially impairing the patient'"'"'s vision.