Transdermal drug delivery device comprising an acrylic block copolymer-based adhesive

• US 7,384,998 B2
• Filed: 01/26/2005
• Issued: 06/10/2008
• Est. Priority Date: 12/21/2002
• Status: Expired due to Term

• Current Assignee: Henkel AG & Co KGaA
• Original Assignee: National Starch and Chemical Investment Holding Corporation
• Inventors: Paul, Charles W., Meisner, Cynthia L.
• Primary Examiner(s): Lipman; Bernard
• Application Number:
  US11/043,474
• Publication Number:
  US 20050228135A1
• Time in Patent Office: 1,231 Days
• Field of Search: 524/376, 524/377, 524/505
• US Class Current: 524/376
• CPC Class Codes: C08F 297/026 polymerising acrylic acid, methacrylic acid or derivatives thereof
• CPC Class Codes: C08L 2666/02 Organic macromolecular compounds, natural resins, waxes or and bituminous materials
• CPC Class Codes: C08L 2666/14 Macromolecular compounds according to C08L59/00 - C08L87/00; Derivatives thereof
• CPC Class Codes: C09J 153/00 Adhesives based on block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Adhesives based on derivatives of such polymers

Abstract

High performance, low viscosity hot melt adhesives are obtained using acrylic block copolymers. The level of acrylic block copolymer in the adhesive formulation is less than 50% by weight.

Claims

1. A transdermal drug delivery device comprising an adhesive layer, a therapeutic agent and a backing layer, wherein the adhesive layer consists of an adhesive composition comprising from about 20 to about 35% by weight, based on the weight of the adhesive composition, of an acrylic block copolymer.

2. The transdermal drug delivery device of claim 1 wherein the adhesive composition comprises said therapeutic agent.

3. The transdermal drug delivery device of claim 2 wherein the therapeutic agent is a drug.

4. The transdermal drug delivery device of claim 1 further comprising a release liner.

5. The transdermal drug delivery device of claim 1 wherein the block copolymer has the formula:

-[A1]-[B]-[A2]-

wherein A1 and A2 each represents a polymer block having a glass transition temperature (Tg) of greater than about 30°

C. and B represents a polymer block having a glass transition temperature of less than about 20°

C.

6. The transdermal drug delivery device of claim 5 wherein polymer block B is present in amounts of at least about 50 weight % based on the weight of the total polymer.

7. The transdermal drug delivery device of claim 5 wherein polymer blocks A1 and A2 are methyl methacrylate and polymer block B is n-butyl acrylate.

8. The transdermal drug delivery device claim 1 wherein the adhesive composition comprises, based on the weight of the adhesive composition, from about 20 to about 35 wt % of an acrylic block copolymer, from about 35 to about 80 wt % of a tackifier, and from about 10 to about 45 wt % of a diluent.

9. The transdermal drug delivery device of claim 1 wherein the block copolymer is prepared by anionic polymerization.