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Sample positioning and analysis system

  • US 7,387,715 B2
  • Filed: 12/31/2002
  • Issued: 06/17/2008
  • Est. Priority Date: 12/17/1997
  • Status: Expired due to Fees
First Claim
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1. A system for analyzing the presence or activity of ion channels in membranous samples, comprising:

  • a carrier having an aperture and a substantially planar seal surface circling the aperture;

    first and second fluid compartments, separated by the carrier, and fluidically connected to one another, in the absence of a membranous sample, via the aperture;

    a membranous sample, selected from the group consisting of cells, organelles, and vesicles, sealed across the aperture, wherein the seal has an electrical resistance of greater than about 1GΩ

    ;

    first and second electrodes, in electrical contact with the first and second fluid compartments, respectively, wherein the first and second electrodes are adapted to apply and/or measure at least one of an electrical potential and a current from at least a portion of the membranous sample sealed across the aperture within the seal surface; and

    a sample-analysis mechanism adapted to perform a fluorescence measurement on a sample positioned about the aperture.

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