Heart monitoring device, system and method

• US 7,389,142 B2
• Filed: 07/30/2003
• Issued: 06/17/2008
• Est. Priority Date: 07/30/2002
• Status: Expired due to Fees

• Current Assignee: St. Jude Medical AB (Abbott Laboratories)
• Original Assignee: St. Jude Medical AB (Abbott Laboratories)
• Inventors: Holmström, Nils
• Primary Examiner(s): Layno; Carl
• Assistant Examiner(s): MORALES, JON ERIC C
• Application Number:
  US10/630,468
• Publication Number:
  US 20040082974A1
• Time in Patent Office: 1,784 Days
• Field of Search: 607/22, 607/18, 607/17, 600/513, 600/364
• US Class Current: 607/18
• CPC Class Codes: A61N 1/365 controlled by a physiological parameter, e.g. heart potential evoked response A61N1/371
• CPC Class Codes: A61N 1/36557 controlled by chemical substances in blood

Abstract

In an implantable heart-monitoring device and system, and a heart-monitoring method, a control circuit is connected to one or more sensors, a first of which is positionable in the coronary sinus region of a heart and senses at least one blood constituent, and at least one other of the sensors supplying a signal to the control circuit indicative of the activity of the heart. In response to signals from the first sensor and with information about the activity of the heart from the other sensor, the control circuit determines a first value of the blood constituent during a first portion of a heart cycle, and determines a second value of the blood constituent during a second portion of the heart cycle.

Claims

1. An implantable heart monitoring device comprising:

a control circuit;

a first sensor adapted to be disposed in a coronary sinus region of a heart to sense blood oxygen in said coronary sinus region, and supplying a first sensor signal representing a blood oxygen level to the control circuit;

at least one further sensor adapted to interact with the heart to sense activity of the heart, said at least one further sensor supplying a further sensor signal representing said activity to the control circuit; and

said control circuit, from said further sensor signal, identifying a first portion in a diastolic portion, and a second portion in a systolic portion, of a same heart cycle of the heart, and from said first sensor signal, determining a first value related to said blood oxygen level that occurs during said first portion and identifying said first value as having occurred during said first portion and determining a second value related to said blood oxygen level that occurs during said second portion and identifying said second value as having occurred during said second portion, and said control circuit emitting an output signal indicative of functioning of the heart dependent on a relation between said first value and said second value.

2. An implantable heart-monitoring device as claimed in claim 1 wherein said control device detects said second value in said second portion within a final 70% of said diastolic portion.

3. An implantable heart-monitoring device as claimed in claim 1 wherein said control circuit detects said first and second values in each of a plurality of heart cycles of the heart.

4. An implantable heart monitoring device as claimed in claim 1 comprising a therapeutic device that executes an action related to cardiac therapy, wherein said control circuit emits a control signal to said therapeutic device that controls said action upon an occurrence selected from the group consisting of said first value fulfilling a predetermined condition, said second value fulfilling a predetermined condition, and a relationship between said first value and said second values fulfilling a predetermined condition.

5. An implantable heart monitoring device as claimed in claim 4 wherein said occurrence is said relationship between said first value and said second value fulfilling a predetermined condition, and wherein said predetermined condition is said first value being lower than a first predetermined level and said second value being higher than a second predetermined level.

6. An implantable heart monitoring device as claimed in claim 4 wherein said occurrence is said relationship between said first value and said second value fulfilling a predetermined condition, and wherein said predetermined condition is said first value decreasing by more than a first predetermined amount over a plurality of heart cycles while said second value decreases less than a second predetermined amount over said plurality of heart cycles.

7. An implantable heart monitoring device as claimed in claim 4 wherein said therapeutic device is a stimulation pulse generator which emits stimulation pulses to the heart, and wherein said action is delivery of said stimulation pulses to the heart.

8. An implantable heart monitoring device as claimed in claim 4 wherein said therapeutic device is a drug delivery device that delivers a drug to a subject in whom said heart monitoring device is implanted, and wherein said action delivery of said drug.

9. An implantable heart-monitoring device as claimed in claim 4 wherein said therapeutic device is a warning signal generator, and wherein said action is to emit a warning signal.

10. An implantable heart monitoring device as claimed in claim 4 further comprising an activity level sensor that senses a level of physical activity of a subject in whom the heart monitoring device is implanted, said activity sensor supplying an activity level signal to said control circuit, and said control circuit determining whether to emit said control signal dependent on said occurrence and said activity level.

11. An implantable heart monitoring system comprising:

a control circuit;

a lead arrangement connected to said control circuit and configured for implantation in a subject;

a first sensor carried by said lead arrangement and adapted to be disposed in a coronary sinus region of a heart to sense blood oxygen in said coronary sinus region, and supplying a first sensor signal representing a blood oxygen level to the control circuit;

at least one further sensor carried by said lead arrangement and adapted to interact with the heart to sense activity of the heart, said at least one further sensor supplying a further sensor signal representing said activity to the control circuit; and

said control circuit, from said further sensor signal, identifying a first portion in a diastolic portion, and a second portion in a systolic portion,

of a same heart cycle of the heart, and from said first sensor signal, determining a first value related to said blood oxygen level that occurs during said first portion and identifying said first value as having occurred during said first portion and determining a second value related to said blood oxygen level that occurs during said second portion and identifying said second value as having occurred during said second portion, and said control circuit emitting an output signal indicative of functioning of the heart dependent on a relation between said first value and said second value.

12. An implantable heart-monitoring system as claimed in claim 11 wherein said control device detects said second value in said second portion within a final 70% of said diastolic portion.

13. An implantable heart-monitoring system as claimed in claim 11 wherein said control circuit detects said first and second values in each of a plurality of heart cycles of the heart.

14. An implantable heart monitoring system as claimed in claim 11 comprising a therapeutic device that executes an action related to cardiac therapy, wherein said control circuit emits a control signal to said therapeutic device that controls said action upon an occurrence selected from the group consisting of said first value fulfilling a predetermined condition, said second value fulfilling a predetermined condition, and a relationship between said first value and said second values fulfilling a predetermined condition.

15. An implantable heart monitoring system as claimed in claim 14 wherein said occurrence is said relationship between said first value and said second value fulfilling a predetermined condition, and wherein said predetermined condition is said first value being lower than a first predetermined level and said second value being higher than a second predetermined level.

16. An implantable heart monitoring system as claimed in claim 14 wherein said occurrence is said relationship between said first value and said second value fulfilling a predetermined condition, and wherein said predetermined condition is said first value decreasing by more than a first predetermined amount over a plurality of heart cycles while said second value decreases less than a second predetermined amount over said plurality of heart cycles.

17. An implantable heart monitoring system as claimed in claim 14 wherein said therapeutic device is a stimulation pulse generator which emits stimulation pulses to the heart, and wherein said action is delivery of said stimulation pulses to the heart.

18. An implantable heart monitoring system as claimed in claim 14 wherein said therapeutic device is a drug delivery device that delivers a drug to a subject in whom said heart monitoring device is implanted, and wherein said action is delivery of said drug.

19. An implantable heart-monitoring system as claimed in claim 14 wherein said therapeutic device is a warning signal generator, and wherein said action is to emit a warning signal.

20. An implantable heart monitoring system as claimed in claim 14 further comprising an activity level sensor that senses a level of physical activity of a subject in whom the heart monitoring device is implanted, said activity sensor supplying an activity level signal to said control circuit, and said control circuit determining whether to emit said control signal dependent on said occurrence and said activity level.

21. An implantable hear monitoring system as claimed in claim 11 wherein said lead arrangement includes a first lead carrying said first sensor, and wherein said implantable heart monitoring system further comprises an electrode also carried on said first lead, said first lead having a distal end and said electrode being carried on said first lead closer to said distal end than said first sensor, and wherein said first lead is configured to introduce said electrode via the coronary sinus into a cardiac vein.

22. An implantable heart monitoring system as claimed in claim 21 wherein said control circuit includes circuitry that generates stimulation pulses, and wherein said stimulation pulses are delivered via said first lead and said electrode.

23. An implantable hear monitoring system as claimed in claim 21 wherein said lead arrangement includes a second lead carrying a further electrode adapted for positioning in the right ventricle of the heart.

24. A heart monitoring method comprising the steps of:

disposing a first sensor in a coronary sinus region of a heart and sensing at least blood oxygen in said coronary sinus region with said first sensor, and generating a first sensor signal representing blood oxygen level;

disposing at least one further sensor adapted to interact with the heart and sensing activity of the heart with said at least one further sensor, and generating a further sensor signal representing said activity; and

from said further sensor signal, electronically identifying a first portion in a diastolic portion, and a second portion in a systolic portion of a same heart cycle of the heart, and from said first sensor signal, electronically determining a first value related to said blood oxygen level that occurs during said first portion and identifying said first value as having occurred during said first portion and a second value related to said blood oxygen level that occurs during said second portion and identifying said second value as having occurred during said second portion, and emitting an output signal indicative of functioning of the heart dependent on a relation between said first value and said second value.

25. A heart monitoring method as claimed in claim 24 comprising electronically detecting said second value in said second portion within a final 70% of said diastolic portion.

26. A heart monitoring method as claimed in claim 24 comprising electronically detecting said first and second values in each of a plurality of heart cycles of the heart.

27. A heart monitoring method as claimed in claim 24 comprising executing a therapeutic action related to cardiac therapy, upon an occurrence selected from the group consisting of said first value fulfilling a predetermined condition, said second value fulfilling a predetermined condition, and a relationship between said first value and said second values fulfilling a predetermined condition.

28. A heart monitoring method as claimed in claim 27 wherein said occurrence is said relationship between said first value and said second value fulfilling a predetermined condition, and wherein said predetermined condition is said first value being lower than a first predetermined level and said second value being higher than a second predetermined level.

29. A heart monitoring method as claimed in claim 27 wherein said occurrence is said relationship between said first value and said second value fulfilling a predetermined condition, and wherein said predetermined condition is said first value decreasing by more than a first predetermined amount over a plurality of heart cycles while said second value decreases less than a second predetermined amount over said plurality of heart cycles.

30. A heart monitoring method as claimed in claim 27 comprising emitting stimulation pulse to the heart, and controlling delivery of said stimulation pulses to the heart as said therapeutic action.

31. A heart monitoring method as claimed in claim 27 comprising delivering a drug to the subject in whom said heart monitoring device is implanted, and controlling delivery of said drug as said therapeutic action.

32. A heart monitoring method as claimed in claim 27 comprising emitting a warning signal as said therapeutic measure.

33. A heart monitoring method as claimed in claim 27 comprising sensing a level of physical activity of the subject in whom the heart monitoring device is implanted, and generating an activity level signal, and electronically determining whether to execute said action dependent on said occurrence and said activity level.