Delivery of a sympatholytic cardiovascular agent to the central nervous system
First Claim
1. A method of delivering a drug dosage from a drug dispenser to receptors of the central nervous system of a patient'"'"'s body to provide a prophylactic cardiac therapy, the method comprising the steps of:
- surgically implanting a drug infusion catheter with a distal drug delivery portion disposed at a predetermined central nervous system site;
coupling a proximal end of the drug infusion catheter to a drug delivery pump;
one of manually triggering and automatically operating the drug delivery pump to discharge a predetermined dosage of a sympatholytic cardiovascular agent to a central nervous system site to provide a prophylactic cardiac therapy to the patient;
surgically implanting a physiologic sensor in the patient'"'"'s body;
operating the physiologic sensor to derive a physiologic parameter associated with one of;
a myocardial ischemia condition, a cardiac arrthytmia condition, an episode of angina, a hypertension condition, and a relatively elevated sympathetic drive condition; and
adjusting the dosage as a function of the monitored physiologic parameter.
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Accused Products
Abstract
A sympatholytic cardiovascular agent delivered by a drug delivery pump to a central nervous system site to alleviate symptoms of acute or chronic cardiac insult or impaired cardiac performance. The drug delivery pump can be external or implantable infusion pump (IIP) coupled with a drug infusion catheter extending to the site. A patient activator can command delivery of a dosage and/or an implantable heart monitor (IHM) coupled with a sensor can detect physiologic parameters associated with cardiac insult or impaired cardiac performance and trigger dosage delivery. The IIP and IHM can be combined into a single implantable medical device (IMD) or can constitute separate IMDs that communicate by any of known communication mechanisms. The sympatholytic cardiovascular agent is one of the group consisting of an alpha-adrenergic agonist and an alpha2-adrenergic agonist (e.g., clonidine, p-aminoclonidine, guanabenz, lidamidine, tizanidine, moxonidine, methyldopa, xylazine, guanfacine, detomidine, medetomidine, and dexmedetomidine).
133 Citations
33 Claims
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1. A method of delivering a drug dosage from a drug dispenser to receptors of the central nervous system of a patient'"'"'s body to provide a prophylactic cardiac therapy, the method comprising the steps of:
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surgically implanting a drug infusion catheter with a distal drug delivery portion disposed at a predetermined central nervous system site; coupling a proximal end of the drug infusion catheter to a drug delivery pump;
one of manually triggering and automatically operating the drug delivery pump to discharge a predetermined dosage of a sympatholytic cardiovascular agent to a central nervous system site to provide a prophylactic cardiac therapy to the patient;surgically implanting a physiologic sensor in the patient'"'"'s body; operating the physiologic sensor to derive a physiologic parameter associated with one of;
a myocardial ischemia condition, a cardiac arrthytmia condition, an episode of angina, a hypertension condition, and a relatively elevated sympathetic drive condition; andadjusting the dosage as a function of the monitored physiologic parameter. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
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Specification