Biodegradable drug delivery material for stent
First Claim
1. A stent constructed of a biodegradable polymer, said polymer comprising an ester content of 20% to 40% of the polymer, wherein the stent degrades from its surface inwardly when subjected to blood flow, such that bulk erosion is effectively precluded.
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Abstract
A stent is fabricated utilizing a polymer that is selected for its tendency to degrade from the surface inwardly rather than undergo bulk erosion so as to substantially reduce the risk of large particles becoming detached and being swept downstream. Such polymer is hydrophobic yet has water-labile linkages interconnecting the monomers. Ester or imide bonds are incorporated in the polymer to render the surface degrading materials suitable for use in stent applications. The stent may be coated with such polymer or may be wholly formed therefrom.
211 Citations
16 Claims
- 1. A stent constructed of a biodegradable polymer, said polymer comprising an ester content of 20% to 40% of the polymer, wherein the stent degrades from its surface inwardly when subjected to blood flow, such that bulk erosion is effectively precluded.
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16. A stent constructed of a biodegradable polymer, the polymer comprising an ester content of 20% to 40% of the polymer, wherein said stent degrades from its surface inwardly when subjected to blood flow, such that bulk erosion is effectively precluded, wherein the polymer has fragments derived from trimellitylimido-L-Tyrosine or 4-hydroxy-L-proline.
Specification