Method of forming a diffusion barrier layer for implantable devices
First Claim
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1. A method of producing a coating on a stent, comprising:
- (a) forming a first layer of a coating on a stent, the first layer including at least one polymer and at least one active ingredient; and
(b) forming a barrier layer on at least a portion of the first layer, the barrier layer comprising(i) particles adapted to reduce a rate of release of the active ingredient from the first layer after insertion of the stent into a biological lumen, and(ii) a first region and a second region, wherein the first region of the barrier layer has a greater particle volume fraction as compared to the second region of the barrier layer.
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Abstract
A method of forming a diffusion barrier for an implantable medical device carrying a therapeutic or bioactive substance is disclosed. The diffusion barrier reduces the rate at which the therapeutic or bioactive substance is released from the device. The diffusion barrier can be made from a polymeric material impregnated with particles.
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22 Claims
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1. A method of producing a coating on a stent, comprising:
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(a) forming a first layer of a coating on a stent, the first layer including at least one polymer and at least one active ingredient; and (b) forming a barrier layer on at least a portion of the first layer, the barrier layer comprising (i) particles adapted to reduce a rate of release of the active ingredient from the first layer after insertion of the stent into a biological lumen, and (ii) a first region and a second region, wherein the first region of the barrier layer has a greater particle volume fraction as compared to the second region of the barrier layer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification