System and method for analyte measurement using AC phase angle measurements
First Claim
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1. A method for determining a glucose concentration of a blood sample, comprising the steps of:
- a) applying a signal having an AC component to the blood sample;
b) measuring an AC phase angle response to the signal; and
c) determining the glucose concentration using the AC phase angle response.
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Abstract
A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the corrected DC response. Other methods and devices are disclosed.
554 Citations
47 Claims
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1. A method for determining a glucose concentration of a blood sample, comprising the steps of:
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a) applying a signal having an AC component to the blood sample; b) measuring an AC phase angle response to the signal; and c) determining the glucose concentration using the AC phase angle response. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of determining a glucose concentration of a biological fluid sample, comprising:
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(a) applying a signal having an AC component to the sample; (b) measuring an AC phase angle response to the signal; and (c) determining the glucose concentration based upon the AC phase angle response and a predetermined correlation between the AC phase angle response and the glucose concentration. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. A method of determining a glucose concentration of a test sample comprising:
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(a) applying a signal having an AC component to the sample; (b) measuring an AC phase angle response to the signal; and (c) determining the glucose concentration using the first AC phase angle response and a predetermined compensation factor. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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36. A method for determining a hematocrit value of a blood sample, comprising the steps of:
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a) applying at least one signal having an AC component to the blood sample, wherein said at least one signal comprises at least two frequencies applied at least partially simultaneously; b) measuring at least one AC phase angle response to respective ones of the at least one signal; and c) determining the hematocrit value using the at least one AC phase angle response. - View Dependent Claims (37, 38)
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39. A method for determining a hematocrit value of a blood sample, comprising the steps of:
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a) applying at least one signal having an AC component to the blood sample; b) measuring at least one AC phase angle response to respective ones of the at least one signal; and c) determining the hematocrit value using the at least one AC phase angle response, wherein said at least one signal comprises n signals, and wherein step (c) comprises determining the hematocrit value using
Hest=c0+c1Φ
1 . . . cnΦ
nWhere; Hest is the hematocrit value, c0, c1 . . . cn are constants, and Φ
1 . . . Φ
n are respective AC phase angle responses to each of the n signals.
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40. A method for determining a hematocrit value of a blood sample, comprising the steps of:
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(a) applying a first signal having an AC component to the blood sample, the first signal having a first frequency; (b) measuring a first AC phase angle response to the first signal; (c) applying a second signal having an AC component to the blood sample, the second signal having a second frequency; (d) measuring a second AC phase angle response to the second signal; and (e) determining the hematocrit value based at least in part upon the first phase angle response and the second phase angle response using
Hest=c0+c1Φ
1 +c2Φ
2Where; Hest is the hematocrit value, c0, c1 and c2 are constants, and Φ
1 and Φ
2 are respective AC phase angle responses to the first and second signals. - View Dependent Claims (41, 42, 43)
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44. A method for determining a hematocrit value of a blood sample, comprising the steps of:
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(a) applying a first signal having an AC component to the blood sample, the first signal having a first frequency; (b) measuring a first AC phase angle response to the first signal; (c) applying a second signal having an AC component to the blood sample, the second signal having a second frequency; (d) measuring a second AC phase angle response to the second signal; and (e) determining the hematocrit value based at least in part upon the first phase angle response and the second phase angle response, wherein the first frequency and the second frequency are applied at least partially simultaneously.
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45. A method for determining a hematocrit value of a blood sample, comprising the steps of:
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(a) applying a first signal having an AC component to the blood sample, the first signal having a first frequency; (b) measuring a first AC phase angle response to the first signal; (c) applying a second signal having an AC component to the blood sample, the second signal having a second frequency; (d) measuring a second AC phase angle response to the second signal; (e) applying a third signal having an AC component to the blood sample, the third signal having a third frequency; (f) measuring a third AC phase angle response to the third signal; (g) applying a fourth signal having an AC component to the blood sample, the fourth signal having a fourth frequency; and (h) measuring a fourth AC phase angle response to the fourth signal; (i) wherein the determining the hematocrit value is further based upon the third phase angle response and the fourth phase angle response, using
Hest=c0+c1Φ
1+c2Φ
2+c3Φ
3+c4Φ
4Where; Hest is the hematocrit value, c0, c1, c2, c3, c4 are constants, and Φ
1, Φ
2, Φ
3, Φ
4 are respective AC phase angle responses to the first, second, third and fourth signals.
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46. A method for determining a hematocrit value of a blood sample, comprising the steps of:
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a) applying at least one signal having an AC component to the blood sample, wherein the AC component comprises a frequency between about 1 kHz and about 20 kHz; b) measuring at least one AC phase angle response to respective ones of the at least one signal; and c) determining the hematocrit value using the at least one AC phase angle response.
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47. A method for determining a hematocrit value of a blood sample, comprising the steps of:
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(a) applying a first signal having an AC component to the blood sample, the first signal having a first frequency between about 1 kHz and about 20 kHz; (b) measuring a first AC phase angle response to the first signal; (c) applying a second signal having an AC component to the blood sample, the second signal having a second frequency; (d) measuring a second AC phase angle response to the second signal; and (e) determining the hematocrit value based at least in part upon the first phase angle response and the second phase angle response.
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Specification