Demand-based cardiac function therapy

• US 7,392,084 B2
• Filed: 09/23/2003
• Issued: 06/24/2008
• Est. Priority Date: 09/23/2003
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Zhu, Qingsheng, KenKnight, Bruce H.
• Primary Examiner(s): Layno; Carl
• Assistant Examiner(s): SARCIONE, JESSICA LYNN
• Application Number:
  US10/669,170
• Publication Number:
  US 20050065554A1
• Time in Patent Office: 1,736 Days
• Field of Search: 607/9, 607/14, 607 17- 27, 607 4- 6, 607/50, 600/513, 600/520, 600526-527
• US Class Current: 607/18
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36842 Multi-site stimulation in the same chamber
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation

Abstract

A method and device for delivering cardiac function therapy on a demand basis. An implantable device for delivering cardiac function therapy is programmed to suspend such therapy at periodic intervals or upon command from an external programmer. Measurements related to hemodynamic performance are then taken using one or more sensing modalities incorporated into the device. Based upon these measurements, the device uses a decision algorithm to determine whether further delivery of the cardiac function therapy is warranted.

Claims

1. A method, comprising:

implanting a cardiac pacing device having a plurality of pacing channels in a patient so as to allow paces to be delivered to a plurality of ventricular sites;

configuring the cardiac pacing device to deliver cardiac function therapy that effects reversal of ventricular remodeling by delivering pacing pulses to one or more stressed or hypertrophied ventricular regions in a manner that pre-excites those region(s) relative to other ventricular regions;

measuring the cardiac output of the patient;

measuring the exertion level of the patient;

configuring the cardiac pacing device to assess the patient'"'"'s cardiac function by comparing the measured cardiac output with the measured exertion level and computing a cardiac function parameter indicative as to whether the patient'"'"'s cardiac output is adequate for the measured exertion level; and

configuring the cardiac pacing device to temporarily suspend delivery of cardiac function therapy, assess the patient'"'"'s cardiac function while no cardiac function therapy is being delivered by comparing the cardiac function parameter to a threshold value, continuing delivery of cardiac function therapy if the patient'"'"'s cardiac function is determined to be inadequate, and ceasing delivery of cardiac function therapy if the patient'"'"'s cardiac function is determined to have improved to a specified extent.

2. The method of claim 1 further comprising measuring cardiac blood volume and wherein the cardiac function parameter is further computed based upon an ejection fraction derived from measurements of end-diastolic and end-systolic volumes.

3. The method of claim 1 further comprising measuring diastolic filling pressures and systolic pulse pressures and wherein the cardiac function parameter is further computed based upon the measured diastolic filling pressures and systolic pulse pressures.

4. The method of claim 1 wherein the cardiac output is measured by measuring a trans-thoracic impedance and heart rate.

5. The method of claim 1 wherein the exertion level measurement is selected from an activity level measurement and a minute ventilation measurement.

6. The method of claim 1 wherein the cardiac function assessment includes an assessment of the patient'"'"'s autonomic balance by measuring the patient'"'"'s heart rate variability.

7. The method of claim 6 further comprising:

measuring and collecting time intervals between successive chamber senses and storing the collected intervals as a discrete RR interval signal, filtering the RR interval signal into defined high and low frequency bands, and determining the signal power of the RR interval signal in each of the low and high frequency bands, referred to LF and HF, respectively; and

,

computing an LF/HF ratio and assessing cardiac function by comparing the LF/HF ratio to a specified ratio threshold value.

8. The method of claim 1 wherein the suspension of cardiac function therapy and assessment of the patient'"'"'s cardiac function are performed upon a command from an external programmer.

9. The method of claim 1 wherein the suspension of cardiac function therapy and assessment of the patient'"'"'s cardiac function are performed at periodic intervals.