Transdermal delivery system for water insoluble drugs
First Claim
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1. A system for transdermal delivery of a water-insoluble drug comprising:
- an apparatus for facilitating transdermal delivery of a drug through skin of a subject, wherein the apparatus comprises;
a. an electrode cartridge comprising a plurality of electrodes; and
b. a main unit comprising a control unit which is adapted to apply electrical energy to the electrodes when the electrodes are in vicinity of the skin, enabling ablation of the stratum corneum in an area beneath the electrodes, thereby generating a plurality of hydrophilic micro-channels; and
a patch adapted to be applied to the area on the skin after the plurality of hydrophilic micro-channels is generated, wherein the patch comprises a pharmaceutical composition comprising at least one water-insoluble drug and at least one carrier molecule that enhances the solubility of the drug in an aqueous solution of fluid coming out of the skin when said plurality of hydrophilic micro-channels is generated, the pharmaceutical composition is devoid of a permeation enhancer.
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Abstract
The present invention provides a system for transdermal delivery of water insoluble drugs and methods using the same. The system includes a pharmaceutical composition of a water insoluble drug and a carrier molecule that enhances the solubility of the drug in aqueous solution, a medical patch containing the same and an apparatus that generates hydrophilic micro-channels in an area of skin of a subject using the composition or patch. The system preferably avoids the use of penetration enhancers and is particularly useful for transdermal delivery of steroids.
93 Citations
39 Claims
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1. A system for transdermal delivery of a water-insoluble drug comprising:
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an apparatus for facilitating transdermal delivery of a drug through skin of a subject, wherein the apparatus comprises; a. an electrode cartridge comprising a plurality of electrodes; and b. a main unit comprising a control unit which is adapted to apply electrical energy to the electrodes when the electrodes are in vicinity of the skin, enabling ablation of the stratum corneum in an area beneath the electrodes, thereby generating a plurality of hydrophilic micro-channels; and a patch adapted to be applied to the area on the skin after the plurality of hydrophilic micro-channels is generated, wherein the patch comprises a pharmaceutical composition comprising at least one water-insoluble drug and at least one carrier molecule that enhances the solubility of the drug in an aqueous solution of fluid coming out of the skin when said plurality of hydrophilic micro-channels is generated, the pharmaceutical composition is devoid of a permeation enhancer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method for transdermal administration of a water-insoluble drug comprising:
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(i) generating a plurality of hydrophilic micro-channels in an area of skin of a subject by an apparatus comprising; a. an electrode cartridge comprising a plurality of electrodes; and b. a main unit comprising a control unit which is adapted to apply electrical energy to the electrodes when the electrodes are in vicinity of the skin, enabling ablation of the stratum corneum in the area beneath the electrodes, thereby generating a plurality of hydrophilic micro-channels; and (ii) affixing a patch to said area of skin in which the plurality of hydrophilic micro-channels is present, wherein the patch comprises a pharmaceutical composition comprising at least one water-insoluble drug and at least one carrier molecule that enhances the solubility of the drug in an aqueous solution of fluids coming out of the skin when said plurality of hydrophilic micro-channels is generated, the pharmaceutical composition is devoid of a permeation enhancer. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A method for transdermal administration of a water-insoluble drug comprising:
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(i) generating a plurality of hydrophilic micro-channels in an area of skin of a subject by an apparatus comprising; a. an electrode cartridge comprising a plurality of electrodes; and b. a main unit comprising a control unit which is adapted to apply electrical energy to the electrodes when the electrodes are in vicinity of the skin, enabling ablation of the stratum corneum in the area beneath the electrodes, thereby generating a plurality of hydrophilic micro-channels; and (ii) affixing a patch to said area of skin in which the plurality of hydrophilic micro-channels is present, wherein the patch comprises a pharmaceutical composition comprising at least one water-insoluble drug and at least one carrier molecule that enhances the solubility of the drug in an aqueous solution of fluids coming out of the skin when said plurality of hydrophilic micro-channels is generated, said pharmaceutical composition is devoid of a permeation enhancer; and (iii) achieving a therapeutic blood concentration of the drug. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39)
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Specification