Lab-on-chip system and method and apparatus for manufacturing and operating same

• US 7,395,474 B2
• Filed: 08/02/2004
• Issued: 07/01/2008
• Est. Priority Date: 08/01/2003
• Status: Active Grant

• Current Assignee: Nytell Software LLC (Intellectual Ventures LLC)
• Original Assignee: Intermec IP Corporation (Honeywell International Inc.)
• Inventors: Payne, Ronald D., Maltseff, Paul A.
• Primary Examiner(s): Ton; David
• Application Number:
  US10/909,920
• Publication Number:
  US 20050066246A1
• Time in Patent Office: 1,429 Days
• Field of Search: 703/20, 607/2, 320/101, 257/678, 340/10.41, 417/53, 714/733, 714/30, 343/895, 356/503, 210/321.84
• US Class Current: 714/733
• CPC Class Codes: G01R 31/2884 using dedicated test connectors, test elements or test circuits on the IC under test G01R31/2855 takes precedence
• CPC Class Codes: G01R 31/3025 Wireless interface with the DUT
• CPC Class Codes: G01R 31/303 of integrated circuits G01R31/305 - G01R31/315 take precedence

Abstract

A lab-on-chip system comprises an antenna and a communications subsystem to wirelessly transmit information from the lab-on-chip system. The communications subsystem may also receive information, data or instructions from an off-chip system or device. The lab-on-chip system may comprise a passive power subsystem coupled to an antenna to wirelessly receive power in the form of an electromagnetic field, which provides electrical power derived therefrom to at least one other subsystem of the lab-on-chip system.

Claims

1. A lab-on-chip system, comprising:

a substrate;

at least a first micro-electrical-mechanical structure formed on at least a portion of the substrate, the first micro-electrical-mechanical structure operable to perform at least one physical action on at least one physical work product;

an antenna carried by the substrate;

a passive power circuit carried by the substrate and coupled to the antenna to wirelessly receive power thereby in the form of an electromagnetic field and coupled to provide power to operate at least the first micro-electrical-mechanical structure;

a controller carried by the substrate and communicatively coupled to control operation of at least the first micro-electrical-mechanical structure by executing a set of instructions; and

a communications circuit carried by the substrate and operable to wirelessly transmit data from and to the lab-on-chip system,

wherein the instructions are receivable via the antenna and the communication circuit.

2. The lab-on-chip system of claim 1, further comprising:

at least a first sensor carried by the substrate and operable to sense at least one operating characteristic of the first micro-electrical-mechanical structure;

a communications circuit carried by the substrate and operable to wirelessly transmit information regarding the at least one operating characteristic of the first micro-electrical-mechanical structure from the lab-on-chip system.

3. The lab-on-chip system of claim 1, further comprising:

at least a first sensor carried by the substrate and operable to sense at least one physical characteristic of the physical work product;

a communications circuit carried by the substrate and operable to wirelessly transmit information regarding the at least one physical characteristic of the physical work product from the lab-on-chip system.

4. The lab-on-chip system of claim 1 wherein the first micro-electrical-mechanical structure comprises at least a first micro-fluidic structure formed on at least a portion of the substrate, the first micro-fluidic structure operable to move at least a first fluid component.

5. The lab-on-chip system of claim 4 wherein the first fluid component is a body of fluid.

6. The lab-on-chip system of claim 4 wherein the first fluid component is a number of particles suspended in a fluid medium.

7. The lab-on-chip system of claim 1 wherein the at least a first micro-electrical-mechanical structure comprises an array of electrodes operable to move at least a first fluid component.

8. The method of claim 1, further comprising a self check subsystem.

9. A lab-on-chip system, comprising:

a substrate;

at least a first micro-electrical-mechanical structure formed on at least a portion of the substrate, the first micro-electrical-mechanical structure operable to perform at least one physical action on at least one physical work product;

an antenna carried by the substrate;

a controller carried by the substrate and communicatively coupled to control operation of at least the first micro-electrical-mechanical structure by executing a set of instructions; and

a communications circuit carried by the substrate, the communications circuit coupled to the antenna and operable to wirelessly transmit information from and to the lab-on-chip system, wherein the instructions are receivable via the antenna and the communication circuit.

10. The lab-on-chip system of claim 9, further comprising:

at least a first sensor carried by the substrate and operable to sense at least one operating characteristic of the first micro-electrical-mechanical structure, wherein the communications circuit is operable to wirelessly transmit information regarding the at least one operating characteristic of the first micro-electrical-mechanical structure from the lab-on-chip system.

11. The lab-on-chip system of claim 9, further comprising:

at least a first sensor carried by the substrate and operable to sense at least one physical characteristic of the physical work product, wherein the communications circuit is operable to wirelessly transmit information regarding the at least one physical characteristic of the physical work product from the lab-on-chip system.

12. The lab-on-chip system of claim 9, further comprising:

a passive power circuit carried by the substrate and coupled to the antenna to wirelessly receive power thereby in the form of an electromagnetic filed and coupled to provide power to operate at least the first micro-electrical-mechanical structure.

13. The lab-on-chip system of claim 9, further comprising:

a controller carried by the substrate and communicatingly coupled to control operation of at least the first micro-electrical-mechanical structure.

14. The lab-on-chip system of claim 9, further comprising:

a controller carried by the substrate and communicatingly coupled to control operation of at least the first micro-electrical-mechanical structure; and

a passive power circuit carried by the substrate and coupled to the antenna to wirelessly receive power thereby in the form of an electromagnetic field and coupled to provide power to operate the controller and at least the first micro-electrical-mechanical structure.

15. The lab-on-chip system of claim 9 wherein the antenna is carried by the substrate.

16. The lab-on-chip system of claim 9, further comprising:

a communications port, wherein the antenna is communicatively coupled to the communications port and the antenna is not carried by the substrate.

17. The lab-on-chip system of claim 9, further comprising:

a power storage device carried by the substrate and coupled to provide power to operate at least the first micro-electrical-mechanical structure.

18. The lab-on-chip system of claim 17 wherein the power storage device comprises at least one of a battery and an ultra-capacitor.

19. The lab-on-chip system of claim 9, further comprising a self check subsystem.

20. A method of operating a lab-on-chip system, the method comprising:

wirelessly receiving an electromagnetic field at an antenna on a substrate;

converting the wireless signal into electrical power;

receiving instructions via the antenna and a communication circuit for a controller; and

driving at least one micro-electrical-mechanical structure with the electrical power, wherein the at least one micro-electrical-mechanical structure is formed on the substrate.

21. The method of claim 20 wherein wirelessly receiving an electromagnetic field at an antenna comprises receiving an radio frequency signal at the antenna.

22. The method of claim 20, further comprising:

supplying a portion of the electrical power to a controller coupled to control operation of the at least one micro-electrical-mechanical structure.

23. The method of claim 20, further comprising:

sensing at least one operating characteristic of the first micro-electrical-mechanical structure; and

wirelessly transmitting information regarding the at least one operating characteristic of the micro-electrical-mechanical structure from the lab-on-chip system.

24. The method of claim 20, further comprising:

sensing at least one operating characteristic of the first micro-electrical-mechanical structure; and

storing information regarding the at least one operating characteristic of the first micro-electrical-mechanical structure on the lab-on-chip system.

25. The method of claim 20, further comprising:

sensing at least one physical characteristic of a physical work product operated on by the first micro-electrical-mechanical structure; and

wirelessly transmitting information regarding the at least one physical characteristic of the physical work product from the lab-on-chip system.

26. The method of claim 20, further comprising:

sensing at least one physical characteristic of the fluid operated on by the first micro-electrical-mechanical structure; and

wirelessly transmitting information regarding the at least one physical characteristic of the fluid from the lab-on-chip system.

27. The method of claim 20 wherein the at least one micro-electrical-mechanical structure is a pump and driving at least one micro-electrical-mechanical structure with the electrical power comprises driving the pump to move a fluid.

28. A method of operating a lab-on-chip system;

the method comprising;

performing with a first micro-electrical-mechanical structure formed on a substrate at least one physical action on a work product;

determining a physical characteristic of the physical work product; and

wirelessly transmitting with an antenna carried on the substrate the determined information from the lab-on-chip system.

29. The method of claim 28, further comprising:

sensing the operating characteristic of the first micro-electrical-mechanical structure.

30. The method of claim 28, further comprising:

wirelessly receiving information at the lab-on-chip system;

controlling operating of the first micro-electrical-mechanical structure based on the received information.

31. The method of claim 28, further comprising:

passively deriving energy to operate the first micro-electrical-mechanical structure from a wireless transmission received at the antenna of the lab-on-chip system.

32. The method of claim 28, further comprising:

sensing the physical characteristic of the physical work product.

33. A method of operating a lab-on-chip system, the method comprising:

wirelessly receiving an electromagnetic field at an antenna;

converting the wireless signal into electrical power; and

using the electrical power to selectively apply respective electrical potentials to each of a plurality of electrodes to move a fluid component in a controlled manner.

34. The method of claim 33 wherein wirelessly receiving an electromagnetic field at an antenna comprises receiving an radio frequency signal at the antenna.

35. The method of claim 33, further comprising:

supplying a portion of the electrical power to a controller coupled to control operation of the plurality of electrodes.

36. The method of claim 33, further comprising:

sensing at least one operating characteristic of at least one of the plurality of electrodes; and

wirelessly transmitting information regarding the at least one operating characteristic from the lab-on-chip system.

37. The method of claim 33, further comprising:

sensing at least one operating characteristic of at least one of the plurality of electrodes; and

storing information regarding the at least one operating characteristic on the lab-on-chip system.

38. The method of claim 33, further comprising:

sensing at least one physical characteristic of the fluid component operated on by the plurality of electrodes; and

wirelessly transmitting information regarding the at least one physical characteristic from the lab-on-chip system.

39. The method of claim 33 wherein the fluid component is a microfluidic body, further comprising:

sensing at least one physical characteristic of the microfluidic body operated on by the plurality of electrodes; and

wirelessly transmitting information regarding the at least one physical characteristic of the microfluidic body from the lab-on-chip system.

40. The method of claim 33 wherein using the electrical power to selectively apply respective electrical potentials to each of a plurality of electrodes to move a fluid component in a controlled manner includes sequentially applying respective electrical potentials to each of at least two of the plurality of electrodes.

41. A method of operating a lab-on-chip system the method comprising:

determining at least one of an operating characteristic of a first micro-electrical-mechanical structure formed on a substrate or a physical characteristic of the physical work product; and

storing the determined information in a memory carried by the substrate.

42. The method of claim 41, further comprising:

sensing the operating characteristic of the first micro-electrical-mechanical structure.

43. The method of claim 41, further comprising:

sensing the physical characteristic of the physical work product.

44. The method of claim 41, further comprising:

passively deriving energy to operate the first micro-electrical-mechanical structure from an electromagnetic field received at an antenna of the lab-on-chip system.