Automated quality control method and system for genetic analysis
First Claim
1. A computer implemented method of automating quality control for genetic analysis data, comprising:
- receiving genetic analysis data associated with at least one spectral species and genetic sample in each well of a plate;
performing one or more genetic analysis related operations on the received genetic analysis data derived for each of the wells of the plate;
identifying at least one of the results from performing the one or more genetic analysis related operations determined to have anomalous characteristics according to a set of one or more quality control metrics; and
flagging one or more wells of the plate affected by the anomalous characteristics according to the set of one or more quality control metrics and making the resulting flagging of the one or more wells available for further processing.
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Abstract
Aspects of the present invention describe a method and apparatus for automating quality control for gene expression data. A computer based device receives gene expression data associated with a spectral species and genetic sample in each well of a plate. Gene expression data may be received from a sequence detection instrument performing one or more gene expression related operations for each of the wells of the plate. The computer based device identifies gene expression data determined to have anomalous characteristics according to a set of one or more quality control metrics and may conditionally flag one or more wells of the plate affected by the anomalous characteristics. Filters can then be selectively applied to temporarily or permanently remove the flagged data from subsequent gene expression studies.
33 Citations
22 Claims
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1. A computer implemented method of automating quality control for genetic analysis data, comprising:
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receiving genetic analysis data associated with at least one spectral species and genetic sample in each well of a plate; performing one or more genetic analysis related operations on the received genetic analysis data derived for each of the wells of the plate; identifying at least one of the results from performing the one or more genetic analysis related operations determined to have anomalous characteristics according to a set of one or more quality control metrics; and flagging one or more wells of the plate affected by the anomalous characteristics according to the set of one or more quality control metrics and making the resulting flagging of the one or more wells available for further processing. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A computer program product for automating quality control for genetic analysis data, tangibly stored on a computer-readable medium, comprising instructions operable to cause a programmable processor to:
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receive genetic analysis data associated with at least one spectral species and genetic sample in each well of a plate; perform one or more genetic analysis related operations on the received genetic analysis data derived for each of the wells of the plate; identify at least one of the results from performing the one or more genetic analysis related operations determined to have anomalous characteristics according to a set of one or more quality control metrics; and flag one or more wells of the plate affected by the anomalous characteristics according to the set of one or more quality control metrics and making the resulting flagging of the one or more wells available for further processing. - View Dependent Claims (19, 20, 21)
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22. An apparatus for automating quality control for genetic analysis data, comprising:
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means for receiving genetic analysis data associated with at least one spectral species and genetic sample in each well of a plate; means for performing one or more genetic analysis related operations on the received genetic analysis data derived for each of the wells of the plate; means for identifying at least one of the results from performing the one or more genetic analysis related operations determined to have anomalous characteristics according to a set of one or more quality control metrics; and means for flagging one or more wells of the plate affected by the anomalous characteristics according to the set of one or more quality control metrics and making the resulting flagging of the one or more wells available for further processing.
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Specification