Method for pulmonary drug delivery
First Claim
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1. A method for the delivery of a therapeutic compound through a chest wall into alveolar tissue of a lung, the method comprising:
- (a) creating one or more localized pleurodeses between the chest wall and the lung;
(b) introducing a therapeutic compound delivery system through the chest wall into the alveolar tissue through at least one of the one or more localized pleurodeses; and
(c) delivering the therapeutic compound through the chest wall into the lung alveolar tissue utilizing the therapeutic compound delivery system.
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Abstract
The local delivery of therapeutic agents directly into the lungs provides a methodology for safely and effectively treating various disease conditions.
357 Citations
20 Claims
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1. A method for the delivery of a therapeutic compound through a chest wall into alveolar tissue of a lung, the method comprising:
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(a) creating one or more localized pleurodeses between the chest wall and the lung; (b) introducing a therapeutic compound delivery system through the chest wall into the alveolar tissue through at least one of the one or more localized pleurodeses; and (c) delivering the therapeutic compound through the chest wall into the lung alveolar tissue utilizing the therapeutic compound delivery system. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method for delivering a therapeutic compound to diseased alveolar tissue of a lung comprising:
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(a) determining the location of the diseased alveolar tissue; (b) creating an adhesion between a visceral membrane of the lung and a thoracic wall at an adhesion site; (c) introducing a therapeutic compound delivery device through the thoracic wall and visceral membrane at the adhesion site into the diseased alveolar tissue; and (d) using the therapeutic compound delivery device to deliver the therapeutic compound through the thoracic wall directly to the diseased alveolar tissue. - View Dependent Claims (9, 10, 11, 12, 13)
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14. A method for the delivery of a therapeutic compound into alveolar tissue of a lung through a visceral membrane of the lung and a thoracic wall wherein the method comprises:
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(a) creating a localized pleurodesis between the thoracic wall and the visceral membrane; (b) introducing a drug delivery device through the thoracic wall and the visceral membrane though the localized pleurodesis and into the alveolar tissue; (c) determining a dose of the therapeutic compound substantially less that the dose that would be inhaled to achieve an equivalent therapeutic effect; and (d) delivering the dose of the therapeutic compound through the visceral membrane and thoracic wall into the alveolar tissue utilizing the drug delivery device. - View Dependent Claims (15, 16, 17, 18, 19, 20)
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Specification