Intraluminal therapeutic patch

• US 7,402,172 B2
• Filed: 10/13/2004
• Issued: 07/22/2008
• Est. Priority Date: 10/13/2004
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Zhong, (Samuel) Sheng-Ping, Dao, (Lenny) Kinh-Luan D., Chin, Yem, Scopton, Paul
• Primary Examiner(s): GHERBI, SUZETTE JAIME J
• Application Number:
  US10/962,689
• Publication Number:
  US 20060079957A1
• Time in Patent Office: 1,378 Days
• Field of Search: 623 111- 151, 606/151, 424/423
• US Class Current: 623/1.42
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61F 2/958 Inflatable balloons for placing stents or stent-grafts
• CPC Class Codes: A61M 2025/0057 Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04

Abstract

The present invention includes systems, methods and apparatus. A system in accord with the present invention may include an intraluminal patch sized to fit within a lumen and an expandable therapeutic delivery device. The patch in this embodiment may have an adhesive region on an exposed surface and a drug reservoir region in communication with the exposed surface. By comparison, a method employing the present invention may include placing an intraluminal patch over an expandable delivery device, advancing the delivery device and the expandable patch to a target site, expanding the delivery device so that the patch adheres to the target site, and contracting and withdrawing the delivery device. In so doing the patch may remain to emit a drug to the target site over a sustained period of time.

Claims

1. A therapeutic delivery system comprising:

an intraluminal patch comprising at least one adhesive region and at least one therapeutic reservoir region, the patch sized to fit within a lumen of a human being, the adhesive region on an exposed surface of the patch;

an expandable delivery device having an expandable balloon, the intraluminal patch being disposed over the expandable balloon; and

a sheath slidably disposed on the expandable delivery device, the sheath positioned to slide over the intraluminal patch.

2. The therapeutic delivery system of claim 1, wherein at least one region of the intraluminal patch is dissolvable in water.

5. The therapeutic delivery system of claim 1, wherein the intraluminal patch further comprises at least one support region, the support region providing additional strength to the patch.

6. The therapeutic delivery system of claim 1, wherein at least one region of the intraluminal patch is formed from a porous polymer platform for growing cells.

7. The therapeutic delivery system of claim 1, wherein at least one region of the intraluminal patch is a memory plastic that has varying degrees of softness depending on its temperature.

8. The therapeutic delivery system of claim 1, wherein the intraluminal patch is folded when disposed on the balloon.

9. The therapeutic delivery system of claim 1 wherein the balloon defines a plurality of micro-orifices.

10. The therapeutic delivery system of claim 1 wherein the release of the drug from the drug region is affected by a release control agent.

11. The therapeutic delivery system of claim 1, where at least one of the regions of the patch is formed from a polymer.

12. The therapeutic delivery system of claim 1, where the adhesive region is formed from a pressure sensitive adhesive.

3. The therapeutic delivery system of clam 1, wherein the intraluminal patch further comprises at least one protective region, the protective region covering the adhesive region.

4. The therapeutic delivery system of claim 3, wherein at least one region of the intraluminal patch dissolves at a preselected rate.

13. A method of delivering therapeutics comprising:

placing an intraluminal patch over an expandable delivery device, the expandable delivery device having an expanded and contracted position, and wherein a sheath is slidably disposed on the expandable delivery device, the sheath positioned to slide over the intraluminal patch;

advancing the delivery device to a target site;

exposing the intraluminal patch by sliding the sheath proximally;

expanding the delivery device so that the patch adheres to the target site;

isolating the target site from surrounding area with said patch;

contracting and withdrawing the delivery device, leaving the patch at the target site; and

emitting a drug from the intraluminal patch to the target site over a sustained period of time.

14. The method of claim 13, further comprising:

absorbing moisture from the target site area into the intraluminal patch.

15. A method of delivering therapeutic comprising:

providing an intraluminal patch having multiple regions, wherein the intraluminal patch is covered by a sheath;

delivering the intraluminal patch to a target site;

bonding the intraluminal patch to the target site;

absorbing moisture into the intraluminal patch; and

releasing a drug from within the intraluminal patch to the target site as the moisture is absorbed by the intraluminal patch.

16. The method of claim 15, further comprising:

dissolving at least one region of the intraluminal patch.