Medical devices having antimicrobial coatings thereon

• US 7,402,318 B2
• Filed: 11/04/2002
• Issued: 07/22/2008
• Est. Priority Date: 11/14/2001
• Status: Active Grant

• Current Assignee: Alcon Incorporated
• Original Assignee: Novartis Ag
• Inventors: Lally, John Martin, Winterton, Lynn Cook, Qiu, Yongxing, Gabriel, Manal M., Ash, Marcia Kay, Carney, Fiona Patricia, Morgan, Courtney Flem, Morris, Carol Ann
• Primary Examiner(s): Hartley; Michael G.
• Assistant Examiner(s): Silverman; Eric E.
• Application Number:
  US10/287,091
• Publication Number:
  US 20030117579A1
• Time in Patent Office: 2,087 Days
• Field of Search: None
• US Class Current: 424/422
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: G02B 1/043 Contact lenses

Abstract

The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial coating including at least one layer of polyquat of formula (I) or (II). The antimicrobial coating on the medical device of the invention has a high antimicrobial efficacy against microorganisms including Gram-positive and Gram-negative bacterial, a low toxicity, low coefficient of friction, and increased hydrophilicity while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial coating thereon.

Claims

1. A medical device, comprising a core material and an antimicrobial surface coating, wherein said antimicrobial surface coating is an LbL coating obtained by using a layer-by-layer deposition technique and comprises at least one polyanionic-polyquat bilayer composed of one layer of a polyanionic material and one layer of the polyquat of formula (1),

2. A medical device of claim 1, wherein said antimicrobial surface coating comprises one or more layers of polyquat of formula (I) in which one of A and B is hexamethylene radical (—

CH₂CH₂CH₂CH₂CH₂CH₂—

) and the respective other one is an n-alkylene group having 6 to 12 carbon atoms.

3. A medical device of claim 1, wherein the medical device is an ophthalmic lens.

4. An ophthalmic lens of claim 3, wherein the ophthalmic lens is a contact lens.

5. A contact lens of claim 4, wherein the antimicrobial surface coating comprises a capping layer of the polyquat of formula (I).

6. A contact lens of claim 4, wherein the antimicrobial surface coating further comprises at least one polyelectrolyte bilayer which is composed of one layer of the polyanionic material and one layer of a polycationic material.

7. A contact lens of claim 6, wherein the polycationic material is selected from the group consisting of poly(allylamine hydrochloride), poly(ethyleneimine), poly(vynylbenzyltriamethylamine), polyaniline, polypyrrole, poly(pyridinium acetylene), and mixtures thereof.

8. A contact lens of claim 4, wherein said core material is a hydrogel.

9. A contact lens of claim 8, wherein said hydrogel is a siloxane-containing polymer.