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Apparatus for the detection of pepsin

  • US 7,402,423 B2
  • Filed: 08/13/2004
  • Issued: 07/22/2008
  • Est. Priority Date: 08/13/2004
  • Status: Expired due to Fees
First Claim
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1. An article for detecting the presence of pepsin suitable to test a subject in a physician'"'"'s office, the subject suspected of suffering from gastroesophageal reflux disease and providing a sample suspected of containing pepsin, the article comprising:

  • a. a solid support comprising a test area surface;

    b. a multiplicity of peptide chains each having a peptide proximal end and a peptide distal end,wherein the peptide distal end comprises a peptide bearing a first tag that interacts with a second tag to provide a detectable chromophoric product,wherein all of said peptide proximal ends are attached to said test area surface of said support, andwherein said peptide chains are cleavable by said pepsin to provide said peptide proximal end attached to said test area surface and said peptide distal end bearing the detectable first tag cleaved from said test area surface.

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