Treatment of Helicobacter with isothiocyanates

• US 7,402,569 B2
• Filed: 03/31/2004
• Issued: 07/22/2008
• Est. Priority Date: 08/21/2000
• Status: Expired due to Term

• Current Assignee: Brassica Foundation for Chemoprotection Research, Inc.
• Original Assignee: Brassica Foundation for Chemoprotection Research, Inc.
• Inventors: Fahey, Jed W.
• Primary Examiner(s): KWON, BRIAN YONG S
• Application Number:
  US10/813,015
• Publication Number:
  US 20040180843A1
• Time in Patent Office: 1,574 Days
• Field of Search: 514/514, 514/515, 514/24, 514/42, 514/23
• US Class Current: 514/42
• CPC Class Codes: A23L 33/10 using additives addition of substantially indigestible substances A23L33/21
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/26 Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
• CPC Class Codes: A61K 31/43 Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula , e.g. penicillins, penems
• CPC Class Codes: A61K 31/7024 Esters of saccharides
• CPC Class Codes: A61K 31/7048 having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin , digitoxin or digoxin
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 35/00 Antineoplastic agents

Abstract

The present invention relates to methods of preventing or inhibiting the growth of Helicobacter through the use of a composition that comprises a glucosinolate, an isothiocyanate or a derivative or metabolite thereof. The present invention also relates to methods of preventing or treating persistent chronic gastritis, ulcers and/or stomach cancer in subjects at risk for, or in need of treatment thereof.

Claims

1. A method of treating a subject having a Helicobacter infection, wherein said method consists essentially of administering an antibacterially effective amount of a food to said subject to treat a Helicobacter infection, said food comprising one or more of a glucosinolate or an isothiocyanate.

2. The method of claim 1, wherein said food is a plant.

3. The method of claim 2, wherein said plant comprises a glucosinolate.

4. The method of claim 2, wherein said plant is selected from the group consisting of one or more of Brassicaceae, Moringaceae, Resedaceae, Bataceae, Bretschneideraceae, Capparaceae, Caricacea, Euphorbiaceae, Gyrostemonaceae, Limnanthaceae, Pentadiplandraceae, Phytolaccaceae, Pittosporaceae, Salvadoraceae, Tovariaceae, and Tropaeolaceae.

5. The method of claim 4, wherein said plant is selected from the group consisting of one or more of broccoli, broccoli sprouts, Brussels sprouts, cabbage, cauliflower, cauliflower sprouts, daikon, horseradish, kale, mustard seed, radish, wasabi, horseradish tree, cabbage tree, mignonette, and dyer'"'"'s rocket.

6. The method of claim 1, further comprising administering an antibiotic to said subject.

7. The method of claim 6, wherein said antibiotic is selected from the group consisting of one or more of amoxycillin and clarithromycin.

8. The method of claim 1, further comprising administering an H₂ inhibitor to said subject.

9. The method of claim 8, wherein said H₂ inhibitor is omeprazol.

10. The method of claim 1, wherein said subject is a human.

11. The method of claim 1, wherein said subject is a non-human animal.

12. The method of claim 1, wherein said subject is a non-human mammal.

13. The method of claim 1, wherein said subject is a non-human primate.

14. A method for inhibiting the growth of Helicobacter, wherein said method consists essentially of administering to said Helicobacter an antibacterially effective amount of a food for inhibiting the growth of Helicobacter, said food comprising one or more of a glucosinolate or an isothiocyanate.

15. The method of claim 14, wherein said food is a plant.

16. The method of claim 14, wherein said plant comprises a glucosinolate.

17. The method of claim 14, wherein said plant is selected from the group consisting of one or more of Brassicaceae, Moringaceae, Resedaceae, Bataceae, Bretschneideraceae, Capparaceae, Caricacea, Euphorbiaceae, Gyrostemonaceae, Limnanthaceae, Pentadiplandraceae, Phytolaccaceae, Pittosporaceae, Salvadoraceae, Tovariaceae, and Tropaeolaceae.

18. The method of claim 17, wherein said plant is selected from the group consisting of one or more of broccoli, broccoli sprouts, Brussels sprouts, cabbage, cauliflower, cauliflower sprouts, daikon, horseradish, kale, mustard seed, radish, wasabi, horseradish tree, cabbage tree, mignonette, and dyer'"'"'s rocket.

19. The method of claim 14, further comprising administering an antibiotic to said Helicobacter.

20. The method of claim 19, wherein said antibiotic is selected from the group consisting of one or more of amoxycillin and clarithromycin.

21. The method of claim 14, further comprising administering an H₂ inhibitor to said Helicobacter.

22. The method of claim 21, wherein said H₂ inhibitor is omeprazol.

23. A method of treating a subject having a Helicobacter infection, comprising administering an antibacterially effective amount of a pharmaceutical composition to said subject to treat a Helicobacter infection, said pharmaceutical composition comprising one or more of a glucosinolate or an isothiocyanate.

24. The method of claim 23, wherein said pharmaceutical composition is administered orally.

25. The method of claim 23, wherein said subject having a Helicobacter infection is suffering from an ulcer.

26. The method of claim 23, wherein said subject is suffering from, or at risk for developing, stomach cancer.

27. The method of claim 23, wherein said Helicobacter is Helicobacter pylori.

28. The method of claim 23, wherein the composition comprises a combination of one or more glucosinolates or isothiocyanates.

29. The method of claim 23, further comprising administering an antibiotic to said subject.

30. The method of claim 29, wherein said antibiotic is selected from the group consisting of one or more of amoxycillin and clarithromycin.

31. The method of claim 23, further comprising administering an H₂ inhibitor to said subject.

32. The method of claim 31, wherein said H₂ inhibitor is omeprazol.

33. The method of claim 23, wherein said subject is a human.

34. The method of claim 23, wherein said subject is a non-human animal.

35. The method of claim 23, wherein said subject is a non-human mammal.

36. The method of claim 23, wherein said subject is a non-human primate.

37. A method of inhibiting the growth of Helicobacter comprising administering to said Helicobacter an antibacterially effective amount of a pharmaceutical composition for inhibiting the growth of Helicobacter, said pharmaceutical composition comprising one or more of a glucosinolate or an isothiocyanate.

38. The method of claim 37, wherein said Helicobacter is Helicobacter pylori.

39. The method of claim 37, wherein the composition comprises a combination of one or more glucosinolates or isothiocyanates.

40. The method of claim 37, further comprising administering an antibiotic to said Helicobacter.

41. The method of claim 40, wherein said antibiotic is selected from the group consisting of one or more of amoxycillin and clarithromycin.

42. The method of claim 37, further comprising administering an H₂ inhibitor to said subject.

43. The method of claim 42, wherein said H₂ inhibitor is omeprazol.