Closed-loop feedback-driven neuromodulation
First Claim
1. A method of managing a neurological disorder, the method comprising:
- measuring one or more signals from a patient;
extracting one or more parameters from the one or more signals that are indicative of the patient'"'"'s neurological disorder;
using the one or more parameters in a non-linear control law to determine parameters of a neuromodulation signal; and
delivering the neuromodulation signal with the parameters determined by the non-linear control law to the patient.
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Accused Products
Abstract
A neurological control system for modulating activity of any component or structure comprising the entirety or portion of the nervous system, or any structure interfaced thereto, generally referred to herein as a “nervous system component.” The neurological control system generates neural modulation signals delivered to a nervous system component through one or more neuromodulators, comprising intracranial (IC) stimulating electrodes and other actuators, in accordance with treatment parameters. Such treatment parameters may be derived from a neural response to previously delivered neural modulation signals sensed by one or more sensors, each configured to sense a particular characteristic indicative of a neurological or psychiatric condition.
587 Citations
32 Claims
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1. A method of managing a neurological disorder, the method comprising:
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measuring one or more signals from a patient; extracting one or more parameters from the one or more signals that are indicative of the patient'"'"'s neurological disorder; using the one or more parameters in a non-linear control law to determine parameters of a neuromodulation signal; and delivering the neuromodulation signal with the parameters determined by the non-linear control law to the patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A system for managing a neurological disorder, the system comprising:
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one or more electrodes that are configured to measure one or more signals from the patient; a signal processor that is in communication with the one or more electrodes, the signal processor adapted to extract one or more parameters from the one or more signals and process the extracted one or more parameters to estimate a neurological disease state or predict a future neurological disease state; and a controller that receives the estimated neurological disease state and uses a non-linear control law to generate a neuromodulation signal for delivery to a nervous system component of the patient. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A method of managing epilepsy, the method comprising:
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measuring one or more EEG signals from the patient; extracting one or more parameters from the one or more EEG signals; estimating a patient'"'"'s epileptic disease state using the extracted one or more parameters; and inputting at least one of the epileptic disease state and one or more extracted parameters into a non-linear control law to determine parameters for a neuromodulation signal that is to be delivered to a nervous system component of the patient. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
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Specification