Hybrid LVEDP monitor

• US 7,404,800 B2
• Filed: 04/13/2005
• Issued: 07/29/2008
• Est. Priority Date: 04/13/2005
• Status: Expired due to Fees

• Current Assignee: Kevin M. Mcintyre
• Original Assignee: Kevin M. Mcintyre
• Inventors: McIntyre, Kevin M.
• Primary Examiner(s): Nasser, Jr.; Robert L.
• Assistant Examiner(s): Toth; Karen E
• Application Number:
  US11/105,306
• Publication Number:
  US 20060235309A1
• Time in Patent Office: 1,203 Days
• Field of Search: 600/485, 600/486
• US Class Current: 600/485
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 7/02 Stethoscopes acoustic details thereof G10K11/00

Abstract

An apparatus for validating a non-invasively obtained estimate of LVEDP includes a non-invasive system for non-invasively obtaining a first estimate of the LVEDP; an invasive system for invasively obtaining a second estimate of the LVEDP concurrent with the first estimate; and a processor for comparing the first and second estimates of the LVEDP.

Claims

1. An apparatus for validating a non-invasively obtained estimate of LVEDP, the apparatus comprising:

a non-invasive system for obtaining a non-invasive estimate of the LVEDP;

an invasive system for obtaining an invasive estimate of the LVEDP concurrent with the non-invasive system; and

a processor for comparing the non-invasive and invasive estimates of the LVEDP;

wherein the non-invasive system includes;

a first amplitude sensor for non-invasively obtaining a first pressure waveform;

a second amplitude sensor for non-invasively obtaining a second pressure waveform;

an event sensor for detecting a time of occurrence of an event in a cardiac cycle; and

a processor in communication with said first and second amplitude sensors and with said event sensor, said processor being configured to select a segment from each of said first and second waveforms and to connect said segments on the basis of said time of occurrence of said event.

2. The apparatus of claim 1, wherein the invasive system comprises a catheter having a pressure sensor mounted at a distal tip thereof.

3. The apparatus of claim 2, wherein the catheter comprises a pulmonary catheter.

4. The apparatus of claim 2, wherein the catheter comprises a left-ventricular catheter.

5. The apparatus of claim 1, wherein the invasive system is configured to generate the invasive estimate on the basis of a measured PCWP.

6. The apparatus of claim 1, wherein the processor is configured to generate calibration data to be applied to the non-invasive estimate to cause the non-invasive estimate to conform to the invasive estimate.

7. The apparatus of claim 1, wherein the non-invasive system comprises a system for non-invasively constructing a left-ventricular pressure waveform.

8. A method for validating a non-invasively obtained estimate of LVEDP, the method comprising:

non-massively obtaining a first estimate of an LVEDP;

invasively obtaining a second estimate of the LVEDP; and

comparing the first and second estimates of the LVEDP;

wherein non-invasively obtaining a first estimate of an LVEDP includes;

non-invasively obtaining a first pressure waveform;

non-invasively obtaining a second pressure waveform;

detecting a time of occurrence of an event in a cardiac cycle; and

selecting a segment from each of the first and second pressure waveforms and connecting the segments on the basis of the time of occurrence of the event.

9. The method of claim 8, wherein invasively obtaining a second estimate comprises positioning a pulmonary catheter to measure a PCWP.

10. The method of claim 9, generating the second estimate on the basis of the measured PCWP.

11. The method of claim 8, further comprising:

generating calibration data on the basis of the first and second estimates, and

applying the calibration data to the first estimate to cause the first estimate to conform to the second estimate.

12. The method of claim 8, wherein obtaining the first estimate comprises non-massively constructing a left-ventricular pressure waveform.

13. A hybrid LVEDP monitor for validating a non-invasively obtained estimate of LVEDP, the monitor comprising:

means for non-invasively obtaining a first estimate of the LVEDP;

means for invasively obtaining a second estimate of the LVEDP concurrent with the first estimate; and

means for validating the first estimate at least in part on the basis of the second estimate;

wherein means for non-invasively obtaining a first estimate of the LVEDP includes;

means for non-invasively obtaining a first pressure waveform;

means for non-invasively obtaining a second pressure waveform;

means for detecting a time of occurrence of an event in a cardiac cycle; and

means for selecting a segment from each of the first and second pressure waveforms and connecting the segments on the basis of the time of occurrence of the event.

14. The apparatus of claim 13, wherein the means for invasively obtaining a second estimate comprises a pulmonary catheter having a pressure sensor mounted at a distal tip thereof.

15. The apparatus of claim 13, wherein the means for invasively obtaining a second estimate comprises means for measuring PCWP.

16. The apparatus of claim 13, further comprising means for generating calibration data to be applied to the first estimate to cause the first estimate to conform to the second estimate.

17. The apparatus of claim 13, wherein the means for non-invasively obtaining a first estimate comprises means for non-invasively constructing a left-ventricular pressure waveform.

18. A computer-readable medium having encoded thereon software for validating a non-invasively obtained estimate of LVEDP, said software comprising instructions for causing a processing system to:

receive data representative of a non-invasively obtained first estimate of an LVEDP; and

receive data representative of an invasively obtained second estimate of the LVEDP; and

compare the first and second estimates of the LVEDP;

wherein the instructions for causing a computer to receive data representative of a non-invasively obtained first estimate of an LVEDP include instructions for causing a computer to;

receive data representative of a non-invasively obtained first pressure waveform;

receive data representative of a non-invasively obtained second pressure waveform;

detect a time of occurrence of an event in a cardiac cycle; and

to

select a segment from each of the first and second pressure waveforms and to connect the segments on the basis of the time of occurrence of the event.