Spectroscopic diagnostic methods and system based on scattering of polarized light
First Claim
1. A light scattering spectroscopic system comprising:
- an optical probe comprising;
an illumination optical fiber extending along a probe central axis;
a plurality of collection optical fibers tilted at different collection angles relative to the probe central axis, the collection optical fibers being held at the different collection angles by a tapered retainer in the probe, such that the optical probe illuminates and collects light from overlapping areas; and
a polarizer that is optically coupled to at least one collection optical fiber;
a light source optically coupled to the illumination optical fiber;
a detector system optically coupled to the first collection optical fiber and the second collection optical fiber, the detector system generating a spectrum from light transmitted by at least one of the first collection fiber and the second collection fiber to the detector system; and
a data processor in communication with the detector system.
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Abstract
The present invention provides systems and methods for the determination of the physical characteristics of a structured superficial layer of material using light scattering spectroscopy. The light scattering spectroscopy system comprises optical probes that can be used with existing endoscopes without modification to the endoscope itself. The system uses a combination of optical and computational methods to detect physical characteristics such as the size distribution of cell nuclei in epithelial layers of organs. The light scattering spectroscopy system can be used alone, or in conjunction with other techniques, such as fluorescence spectroscopy and reflected light spectroscopy.
47 Citations
39 Claims
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1. A light scattering spectroscopic system comprising:
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an optical probe comprising; an illumination optical fiber extending along a probe central axis; a plurality of collection optical fibers tilted at different collection angles relative to the probe central axis, the collection optical fibers being held at the different collection angles by a tapered retainer in the probe, such that the optical probe illuminates and collects light from overlapping areas; and a polarizer that is optically coupled to at least one collection optical fiber; a light source optically coupled to the illumination optical fiber; a detector system optically coupled to the first collection optical fiber and the second collection optical fiber, the detector system generating a spectrum from light transmitted by at least one of the first collection fiber and the second collection fiber to the detector system; and a data processor in communication with the detector system. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39)
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Specification