Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules
First Claim
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1. A lipid nanoparticle (LNP) composition comprising one or more short interfering nucleic acid (siNA) molecules, 3-Dimethylamino-2-(Cholest-5-en-3β
- -oxybutan-4-oxy)-1-(cis,cis-9,12-octadecadienoxy) propane (CLinDMA), distearoylphosphatidylcholine (DSPC), Cholesterol, and 1-[8′
-(1,2-Dimyristoyl-3-propanoxy)-carboxamido-3′
,6′
-dioxaoctanyl]carbamoyl-ω
-methyl-poly(ethylene glycol) (PEG-DMG).
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Abstract
The present invention relates to novel cationic lipids, transfection agents, microparticles, nanoparticles, and short interfering nucleic acid (siNA) molecules. Specifically, the invention relates to novel cationic lipids, microparticles, nanoparticles and transfection agents that effectively transfect or deliver short interfering nucleic acid (siNA). The compositions described herein are generally referred to as formulated molecular compositions (FMC) or lipid nanoparticles (LNP).
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Citations
10 Claims
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1. A lipid nanoparticle (LNP) composition comprising one or more short interfering nucleic acid (siNA) molecules, 3-Dimethylamino-2-(Cholest-5-en-3β
- -oxybutan-4-oxy)-1-(cis,cis-9,12-octadecadienoxy) propane (CLinDMA), distearoylphosphatidylcholine (DSPC), Cholesterol, and 1-[8′
-(1,2-Dimyristoyl-3-propanoxy)-carboxamido-3′
,6′
-dioxaoctanyl]carbamoyl-ω
-methyl-poly(ethylene glycol) (PEG-DMG). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
- -oxybutan-4-oxy)-1-(cis,cis-9,12-octadecadienoxy) propane (CLinDMA), distearoylphosphatidylcholine (DSPC), Cholesterol, and 1-[8′
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