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Use of Acrp30 globular head to promote increases in muscle mass and muscle differentiation

  • US 7,405,193 B2
  • Filed: 05/22/2001
  • Issued: 07/29/2008
  • Est. Priority Date: 05/31/2000
  • Status: Expired due to Fees
First Claim
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1. A method of accelerating skeletal muscle cell differentiation, comprising contacting skeletal muscle cells in vitro with gOBG3 polypeptides consisting of:

  • amino acids 101-244 of SEQ ID NO;

    6, amino acids 108-244 of SEQ ID NO;

    6, amino acids 104-247 of SEQ ID NOs;

    2 or 4, or amino acids 111-247 of SEQ ID NOs;

    2 or 4, or variants thereof comprising polyethylene glycol conjugated to gOBG3 polypeptides consisting of;

    amino acids 101-244 of SEQ ID NO;

    6, amino acids 108-244 of SEQ ID NO;

    6, amino acids 104-247 of SEQ ID NOs;

    2 or 4, or amino acids 111-247 of SEQ ID NOs;

    2 or 4, wherein said gOBG3 accelerates the differentiation of said cells.

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