Disposable, self-administered electrolyte test

• US 7,407,570 B2
• Filed: 03/13/2003
• Issued: 08/05/2008
• Est. Priority Date: 03/13/2002
• Status: Expired due to Fees

• Current Assignee: Charles Stark Draper Laboratory Incorporated
• Original Assignee: Charles Stark Draper Laboratory Incorporated
• Inventors: Williams, John R., Dineen, Andrew, Prince, Jennifer Ryan
• Primary Examiner(s): NOGUEROLA, ALEXANDER STEPHAN
• Application Number:
  US10/388,198
• Publication Number:
  US 20030201192A1
• Time in Patent Office: 1,972 Days
• Field of Search: 204416-418, 204/409, 204/411, 205/775, 205/789, 205/789.5, 205/787, 205/792, 422/82.01, 422/82.03, 422/58
• US Class Current: 205/792
• CPC Class Codes: A61B 10/0051 for taking saliva or sputum samples devices for receiving spittle A61J9/00
• CPC Class Codes: A61B 10/0064 for taking sweat or sebum samples measuring sweat production A61B5/4266
• CPC Class Codes: A61B 10/007 for taking urine samples measuring urological functions A61B5/20; genital receptacles A61F5/451; urinals for bed-ridden persons A61G9/006
• CPC Class Codes: G01N 27/333 Ion-selective electrodes or membranes glass electrodes G01N27/36
• CPC Class Codes: G01N 33/48785 Electrical and electronic details of measuring devices for physical analysis of liquid biological material not specific to a particular test method, e.g. user interface or power supply

Abstract

A disposable, self-administered electrolyte test is affixed to the label of a commercially available electrolyte supplement, is available in the pharmacy section of a retail store, or is distributed by a physician or a clinic.

Claims

1. A disposable electrolyte test in the form of a substantially flat package, the electrolyte test comprising:

a. a flat, planar substrate;

b. a sample-receiving region on the substrate;

c. an ion-sensor cartridge in fluid communication with the sample-receiving region, the ion-sensor cartridge comprising an ion-selective layer for passing only certain species of a sample to an electrode layer;

d. an indicator on the substrate adjacent the sample-receiving region, wherein the indicator comprises a plurality of indicator elements for indicating a concentration level of an electrolyte within the sample;

e. circuitry for operating the ion-sensor cartridge and the indicator so as to cause display, on the indicator, of an ionic parameter in response to the presence of the sample on the sample-receiving region; and

f. a flexible cover affixed over the substrate so as to be unsealable therefrom and to thereby expose the sample-receiving region,

wherein the disposable electrolyte test is configured to conformably affix to a curved surface of a fluid container.

2. The electrolyte test of claim 1 wherein the circuitry comprises a power source.

3. The electrolyte test of claim 2 wherein the power source is a printed battery.

4. The electrolyte test of claim 1 wherein the ion-sensor cartridge further comprises a plurality of ion-selective electrodes.

5. The electrolyte test of claim 4 wherein the substrate, electrodes, indicator and circuitry are integrated such that the electrolyte test retains a substantially flat, planar profile.

6. The electrolyte test of claim 5 wherein the substrate has first and second sides, the sample-receiving region and the indicator being located on the first side of the substrate, the second side of the substrate comprising an adhesive facilitating affixation of the ion-sensor cartridge and the circuitry onto a surface.

7. The electrolyte test of claim 1 wherein the ionic parameter is an electrolyte level.

8. The electrolyte test of claim 1 wherein the ion-selective layer comprises a semi-permeable membrane.

9. The electrolyte test of claim 8 wherein the semi-permeable membrane is adapted to be permeable to at least one of H⁺, Na⁺, K⁺, Li⁺, Ag⁺, Ca²⁺, Cd²⁺, Ba²⁺, Mg²⁺, Cu²⁺, Pb²⁺, Hg²⁺, Cu²⁺, Fe³⁺, ammonium ions (NH₄⁺), Cl⁻

, Br⁻

, I⁻

, F⁻

, CN⁻

, OCl⁻

, perchlorate (ClO₄⁻

), thiocyanate (SCN⁻

), sulphide (S⁻

), nitrate (NO₃⁻

), nitrite (NO₂⁻

), sulfate (SO₃⁻

), carbonate (CO₃⁻

), bicarbonate (HCO₃⁻

), and S₂O₃².

10. The electrolyte test of claim 1 wherein the ion-selective layer comprises a doped polymetric layer.

11. A method of performing an electrolyte test, the method comprising:

a. providing an electrolyte test element comprising a flat, planar substrate, a sample-receiving region on the substrate, an ion-sensor cartridge in fluid communication with the sample-receiving region, an indicator responsive to the ion-sensor cartridge, and a flexible cover over the substrate so as to be unsealable therefrom and to thereby expose the sample-receiving region;

b. receiving a sample of saliva on the sample-receiving region; and

c. operating the ion-sensor cartridge and the indicator so as to cause display, on the indicator, of an ionic parameter of the sample, wherein the electrolyte test element is configured to conformably affix to a curved surface of a fluid container.

12. The method of claim 11 wherein the test element further comprises circuitry and a power source.

13. The method of claim 12 wherein the power source is a printed battery.

14. The method of claim 11 wherein the ion-sensor cartridge comprises a plurality of ion-selective electrodes.

15. The method of claim 11 further comprising the step of affixing the test element onto a surface of the fluid container.

16. The method of claim 11 wherein the ionic parameter is an electrolyte level.